Reactome | KRTAP4-2 [cytosol]

KRTAP4-2 [cytosol]

Stable Identifier

R-HSA-6809948

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Keratin-associated protein 4-2, KRA42_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of hair keratin fibres (Homo sapiens)
    - Keratin associated proteins [cytosol] (Homo sapiens)
      - KRTAP4s [cytosol] (Homo sapiens)
        
        KRTAP4-2 [cytosol] (Homo sapiens)
    - Keratin tonofilament:Keratin associated proteins polymer [cytosol] (Homo sapiens)
      - Keratin tonofilament, KAPs [cytosol] (Homo sapiens)
        
        Keratin associated proteins [cytosol] (Homo sapiens)
        
        KRTAP4s [cytosol] (Homo sapiens)
        
        KRTAP4-2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BYR5 KRTAP4-2

Gene Names

KRTAP4-2, KAP4.2, KRTAP4.2

Chain

chain:1-136

Reference Genes

BioGPS Gene:85291 KRTAP4-2

COSMIC (genes):KRTAP4-2 KRTAP4-2

CTD Gene:85291 KRTAP4-2

dbSNP Gene:85291 KRTAP4-2

ENSEMBL:ENSG00000244537 KRTAP4-2

ENSEMBL_homo_sapiens_GENE:ENSG00000244537.3 KRTAP4-2

HGNC:18900 KRTAP4-2

KEGG Gene (Homo sapiens):85291 KRTAP4-2

Monarch:85291 KRTAP4-2

NCBI Gene:85291 KRTAP4-2

UCSC:Q9BYR5 KRTAP4-2

Reference Transcript

RefSeq:NM_033062.3 KRTAP4-2

Other Identifiers

11742162_at

16844622

234671_PM_at

234671_at

3756741

3756757

3756774

3756777

3756778

3756820

3756821

3756822

3756823

3756824

3756825

8015242

85291

A_23_P49988

GE558311

GO:0005515

GO:0005829

GO:0005856

GO:0005882

GO:0042802

GO:0043226

GO:0045095

HMNXSV003045510

Hs.307024.0.S1_3p_at

ILMN_2059165

PH_hs_0018470

TC17002905.hg

Participates

as a member of

KRTAP4s [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_149051.1

OpenTargets

ENSG00000244537

GeneCards

Q9BYR5

HPA

ENSG00000244537-KRTAP4-2

Ensembl

ENSG00000244537, ENST00000377726, ENSP00000366955

PRO

Q9BYR5

Pharos - Targets

Q9BYR5

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.718	10
UniProt:Q92608 DOCK2	3	DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [cytosol] (R-HSA-200938)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:Q9NQS3 NECTIN3	1	PVRL3 [plasma membrane] (R-HSA-449762)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.556	3
UniProt:Q9Y5Q3 MAFB	1	MAFB [nucleoplasm] (R-HSA-3788667)	0.556	3
UniProt:Q92570 NR4A3	1	NR4A3 [nucleoplasm] (R-HSA-8938004)	0.556	3
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.556	3
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:Q9UBX3 SLC25A10	1	SLC25A10 [mitochondrial inner membrane] (R-HSA-372848)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	3
UniProt:P43353 ALDH3B1	3	ALDH3B1 [plasma membrane] (R-HSA-5696096) ALDH3B1 [specific granule membrane] (R-HSA-6799510) ALDH3B1 [secretory granule membrane] (R-HSA-6801023)	0.488	2

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