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PVRL3 [plasma membrane]
Stable Identifier
R-HSA-449762
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Nectin-3, Poliovirus receptor-related protein 3, PVRL3_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Cis-homodimerization of nectins (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin cis-homodimer [plasma membrane] (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Interaction of Nectins with Afadin (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin:afadin [plasma membrane] (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin/Necl trans heterodimerization (Homo sapiens)
Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)
Necl-1:Nectin-3 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Necl-2:Nectin 3 trans heterodimer interaction (Homo sapiens)
Nectin-3:Necl-2 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin-1:PVRL3 trans heterodimer formation (Homo sapiens)
Nectin-1:PVRL3 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin-2:Nectin 3 trans heterodimer interaction (Homo sapiens)
Nectin-2:PVRL3 transheterodimer [cell junction] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVR:PVRL3 trans heterodimer interaction (Homo sapiens)
PRV:PVRL3 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Transhomodimerization of Nectins (Homo sapiens)
Nectin cis-homodimer [plasma membrane] (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin trans homodimer [cell junction] (Homo sapiens)
Nectin cis-homodimer [plasma membrane] (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQS3 NECTIN3
Gene Names
NECTIN3, PRR3, PVRL3
Chain
signal peptide:1-57, chain:58-549
Reference Genes
BioGPS Gene:25945 NECTIN3
COSMIC (genes):NECTIN3 NECTIN3
COSMIC (genes):PRR3 NECTIN3
CTD Gene:25945 NECTIN3
dbSNP Gene:25945 NECTIN3
ENSEMBL:ENSG00000177707 NECTIN3
HGNC:17664 NECTIN3
KEGG:hsa:25945 NECTIN3
Monarch:25945 NECTIN3
NCBI Gene:25945 NECTIN3
OMIM:607147 NECTIN3
UCSC:Q9NQS3 NECTIN3
Reference Transcript
RefSeq:NM_001243288.1 NECTIN3
RefSeq:NM_001243286.1 NECTIN3
RefSeq:NM_015480.2 NECTIN3
Participates
as a member of
Nectin [plasma membrane] (Homo sapiens)
as a component of
Necl-1:Nectin-3 trans heterodimer [cell junction] (Homo sapiens)
PRV:PVRL3 trans heterodimer [cell junction] (Homo sapiens)
Nectin-3:Necl-2 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
as an input of
Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)
PVR:PVRL3 trans heterodimer interaction (Homo sapiens)
Necl-2:Nectin 3 trans heterodimer interaction (Homo sapiens)
Inferred To
NECTIN3 [plasma membrane]
(Bos taurus)
NECTIN3 [plasma membrane]
(Canis familiaris)
NECTIN3 [plasma membrane]
(Gallus gallus)
NECTIN3 [plasma membrane]
(Sus scrofa)
nectin3 [plasma membrane]
(Danio rerio)
igcm-3 [plasma membrane]
(Caenorhabditis elegans)
Fas3 [plasma membrane]
(Drosophila melanogaster)
Nectin3 [plasma membrane]
(Mus musculus)
Nectin3 [plasma membrane]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000485303
,
ENSP00000321514
,
ENSP00000418070
,
ENSP00000420579
,
ENST00000493615
,
ENST00000319792
,
ENSG00000177707
OpenTargets
ENSG00000177707
GeneCards
NECTIN3
HPA
ENSG00000177707-NECTIN3
PRO
Q9NQS3
Pharos - Targets
Q9NQS3
GlyGen
Q9NQS3
PDB
4FOM
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92692 NECTIN2
1
PVRL2 [plasma membrane]
(R-HSA-419006)
0.702
4
UniProt:Q15223 NECTIN1
1
PVRL1 [plasma membrane]
(R-HSA-3008842)
0.688
4
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.666
4
UniProt:P55196 AFDN
0.646
4
IntAct:EBI-10171679 386682
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:O76081 RGS20
1
RGS20 [plasma membrane]
(R-HSA-921136)
0.556
3
UniProt:P21333-2 FLNA
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
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