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PVRL3 [plasma membrane]
Stable Identifier
R-HSA-449762
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Nectin-3, Poliovirus receptor-related protein 3, PVRL3_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Cis-homodimerization of nectins (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin cis-homodimer [plasma membrane] (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Interaction of Nectins with Afadin (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin:afadin [plasma membrane] (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin/Necl trans heterodimerization (Homo sapiens)
Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)
Necl-1:Nectin-3 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Necl-2:Nectin 3 trans heterodimer interaction (Homo sapiens)
Nectin-3:Necl-2 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin-1:PVRL3 trans heterodimer formation (Homo sapiens)
Nectin-1:PVRL3 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin-2:Nectin 3 trans heterodimer interaction (Homo sapiens)
Nectin-2:PVRL3 transheterodimer [cell junction] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVR:PVRL3 trans heterodimer interaction (Homo sapiens)
PRV:PVRL3 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Transhomodimerization of Nectins (Homo sapiens)
Nectin cis-homodimer [plasma membrane] (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
Nectin trans homodimer [cell junction] (Homo sapiens)
Nectin cis-homodimer [plasma membrane] (Homo sapiens)
Nectin [plasma membrane] (Homo sapiens)
PVRL3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQS3 NECTIN3
Gene Names
NECTIN3, PRR3, PVRL3
Chain
signal peptide:1-57, chain:58-549
Reference Genes
BioGPS Gene:25945 NECTIN3
COSMIC (genes):NECTIN3 NECTIN3
CTD Gene:25945 NECTIN3
dbSNP Gene:25945 NECTIN3
ENSEMBL:ENSG00000177707.11 NECTIN3
HGNC:17664 NECTIN3
KEGG Gene (Homo sapiens):25945 NECTIN3
Monarch:25945 NECTIN3
NCBI Gene:25945 NECTIN3
OMIM:607147 NECTIN3
UCSC:Q9NQS3 NECTIN3
Reference Transcript
RefSeq:NM_001243288.1 NECTIN3
RefSeq:NM_015480.2 NECTIN3
RefSeq:NM_001243286.1 NECTIN3
Other Identifiers
11727125_a_at
11758970_a_at
213325_PM_at
213325_at
25945
2635646
2635647
2635648
2635649
2635650
2635658
2635659
2635662
2635663
2635664
2635665
2635666
2635668
2635669
2635670
2635671
2635672
2635673
2635674
2635675
2635676
2635677
2635678
2635679
2635680
2635686
2635688
2635700
2635701
2635702
34202_at
52424_r_at
62947_at
8081548
86478_at
A_14_P108380
A_14_P114827
A_14_P133366
A_21_P0014108
A_23_P401547
A_23_P80759
A_23_P80763
A_24_P225862
GE82009
GO:0002089
GO:0005515
GO:0005886
GO:0005911
GO:0005912
GO:0007155
GO:0007156
GO:0007157
GO:0007286
GO:0009566
GO:0016020
GO:0022414
GO:0030154
GO:0042802
GO:0042803
GO:0043226
GO:0043296
GO:0044291
GO:0045202
GO:0045211
GO:0048856
GO:0050839
GO:0060042
GO:0061951
GO:0072659
GO:0098609
GO:0098686
GO:0098839
GO:1902414
HMNXSV003002470
HMNXSV003046933
Hs.21201.0.S2_3p_at
ILMN_1727633
ILMN_2188521
PH_hs_0025521
PH_hs_0035997
Participates
as a member of
Nectin [plasma membrane] (Homo sapiens)
as a component of
Necl-1:Nectin-3 trans heterodimer [cell junction] (Homo sapiens)
PRV:PVRL3 trans heterodimer [cell junction] (Homo sapiens)
Nectin-3:Necl-2 trans heterodimer [cell junction] (Homo sapiens)
PVRL3 dimer [plasma membrane] (Homo sapiens)
as an input of
Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)
PVR:PVRL3 trans heterodimer interaction (Homo sapiens)
Necl-2:Nectin 3 trans heterodimer interaction (Homo sapiens)
Inferred To
NECTIN3 [plasma membrane]
(Bos taurus)
NECTIN3 [plasma membrane]
(Gallus gallus)
NECTIN3 [plasma membrane]
(Sus scrofa)
nectin3 [plasma membrane]
(Danio rerio)
nectin3 [plasma membrane]
(Xenopus tropicalis)
PVRL3 [plasma membrane]
(Canis familiaris)
Nectin3 [plasma membrane]
(Mus musculus)
Nectin3 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001230215.1
,
NP_001230217.1
,
NP_056295.1
OpenTargets
ENSG00000177707
GeneCards
Q9NQS3
HPA
ENSG00000177707-NECTIN3
Ensembl
ENST00000485303
,
ENSG00000177707
,
ENST00000493615
,
ENSP00000418070
,
ENST00000319792
,
ENSP00000321514
,
ENSP00000420579
PRO
Q9NQS3
Pharos - Targets
Q9NQS3
Orphanet
26409
PDB
4FOM
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z3S9 NT2NA
0.666
4
UniProt:P55196 AFDN
0.646
4
UniProt:Q92692 NECTIN2
1
PVRL2 [plasma membrane]
(R-HSA-419006)
0.609
3
UniProt:Q15223 NECTIN1
1
PVRL1 [plasma membrane]
(R-HSA-3008842)
0.589
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:O76081 RGS20
1
RGS20 [plasma membrane]
(R-HSA-921136)
0.556
3
UniProt:P21333-2 FLNA
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
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