Reactome | PLK2 [cytosol]

PLK2 [cytosol]

Stable Identifier

R-HSA-6801636

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase PLK2, Polo-like kinase 2, Serine/threonine-protein kinase SNK, SNK

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        CD163 mediating an anti-inflammatory response (Homo sapiens)
        
        PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)
        
        PLK2, MAPK14 [cytosol] (Homo sapiens)
        
        PLK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYY3 PLK2

Gene Names

PLK2, SNK

Chain

chain:1-685

Reference Genes

BioGPS Gene:10769 PLK2

COSMIC (genes):PLK2 PLK2

CTD Gene:10769 PLK2

dbSNP Gene:10769 PLK2

ENSEMBL:ENSG00000145632 PLK2

HGNC:19699 PLK2

KEGG:hsa:10769 PLK2

Monarch:10769 PLK2

NCBI Gene:10769 PLK2

OMIM:607023 PLK2

UCSC:Q9NYY3 PLK2

Reference Transcript

Other Identifiers

10769

11722162_a_at

11722163_x_at

11746837_a_at

11755161_s_at

16996433

201939_PM_at

201939_at

2858022

2858024

2858025

2858026

2858027

2858028

2858029

2858030

2858031

2858032

2858033

2858034

2858035

2858036

2858037

2858038

2858039

2858040

2858041

2858042

2858043

2858044

2858045

2858046

2858047

2858048

2858049

2858050

2858051

2858052

2858053

41544_at

8112202

A_23_P30254

GE54551

GO:0000082

GO:0000278

GO:0000776

GO:0000785

GO:0000922

GO:0002862

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0006468

GO:0006977

GO:0007010

GO:0007052

GO:0007265

GO:0007613

GO:0010508

GO:0016525

GO:0016740

GO:0018105

GO:0030425

GO:0032486

GO:0042995

GO:0043008

GO:0043066

GO:0043123

GO:0043226

GO:0045732

GO:0046599

GO:0048167

GO:0050877

GO:0060291

GO:0060292

GO:0071866

GO:0090050

GO:0106310

GO:0140096

GO:2000773

HMNXSV003048616

ILMN_1717706

PH_hs_0024593

TC05001385.hg

g5730054_3p_at

Participates

as a member of

PLK2, MAPK14 [cytosol] (Homo sapiens)

as an output of

Inferred To

PLK2 [cytosol] (Bos taurus)

PLK2 [cytosol] (Canis familiaris)

PLK2 [cytosol] (Danio rerio)

PLK2 [cytosol] (Gallus gallus)

PLK2 [cytosol] (Mus musculus)

PLK2 [cytosol] (Rattus norvegicus)

PLK2 [cytosol] (Sus scrofa)

PLK2 [cytosol] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

2169

ENSEMBL

ENSG00000145632, ENST00000274289, ENSP00000274289

OpenTargets

ENSG00000145632

ZINC - FDA approved

PLK2_HUMAN

ZINC - Substances

PLK2_HUMAN

ZINC - Biogenic

PLK2_HUMAN

ZINC target

Q9NYY3

PRO

Q9NYY3

PDB

4I6H, 4I5M, 4RS6, 4I6B, 4I5P, 4XB0, 4I6F

ZINC - Investigational

PLK2_HUMAN

GeneCards

PLK2

HPA

ENSG00000145632-PLK2

Pharos - Targets

Q9NYY3

ZINC - Predictions - Purchasable

PLK2_HUMAN

HMDB Protein

HMDBP01434

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86Y33 CD20B			0.556	3
UniProt:Q8IW75 SPA12			0.527	2
UniProt:Q8IWZ8 SUGP1	1	SUGP1 [nucleoplasm] (R-HSA-72043)	0.527	2
UniProt:Q9H1E1 RNASE7	1	RNASE7 [extracellular region] (R-HSA-6803118)	0.527	2
UniProt:O60911 CTSV	4	CTSL2 [endolysosome lumen] (R-HSA-4127477) CTSL2 [extracellular region] (R-HSA-2228669) CTSL2 [early endosome lumen] (R-HSA-4127471) CTSL2 [lysosomal lumen] (R-HSA-1181232)	0.527	2
UniProt:Q9UI42 CBPA4			0.527	2
UniProt:O75635 SPB7			0.527	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.527	2
UniProt:Q8NEX9 SDR9C7	1	SDR9C7 [endoplasmic reticulum membrane] (R-HSA-4084690)	0.527	2