Reactome | TP53 stimulates PLK2 expression

TP53 stimulates PLK2 expression

Stable Identifier

R-HSA-6801637

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        TP53 stimulates PLK2 expression (Homo sapiens)

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Binding of TP53 to p53 binding site(s) in the promoter of the PLK2 gene stimulates PLK2 transcription. PLK2 may be involved in prevention of the mitotic catastrophe after spindle damage (Burns et al. 2003). PLK2 is frequently transcriptionally silenced through promoter methylation in B-cell malignancies (Syed et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12897130	Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells Burns, TF, Fei, P, Scata, KA, Dicker, DT, El-Deiry, WS	Mol. Cell. Biol.	2003
16160013	Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies Syed, N, Smith, P, Sullivan, A, Spender, LC, Dyer, M, Karran, L, O'Nions, J, Allday, M, Hoffmann, I, Crawford, D, Griffin, B, Farrell, PJ, Crook, T	Blood	2006