Binding of TP53 to p53 binding site(s) in the promoter of the PLK2 gene stimulates PLK2 transcription. PLK2 may be involved in prevention of the mitotic catastrophe after spindle damage (Burns et al. 2003). PLK2 is frequently transcriptionally silenced through promoter methylation in B-cell malignancies (Syed et al. 2006).
Burns, TF, Fei, P, Scata, KA, Dicker, DT, El-Deiry, WS
Syed, N, Smith, P, Sullivan, A, Spender, LC, Dyer, M, Karran, L, O'Nions, J, Allday, M, Hoffmann, I, Crawford, D, Griffin, B, Farrell, PJ, Crook, T
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