NPAS4 stimulates PLK2 gene expression

Stable Identifier
R-HSA-9769177
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NPAS4 stimulates PLK2 gene expression
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Based on studies in mouse (Weng et al. 2018) and rat (Brigidi et al. 2019) neurons, NPAS4 stimulates transcription of the PLK2 gene. PLK2 is a serine/threonine kinase that regulates formation of synapses between hippocampal mossy fibers and CA3 pyramidal neurons, which are essential for contextual memory encoding (Weng et al. 2018).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):PLK2 gene [nucleoplasm] (Homo sapiens)
Active Unit
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2) [nucleoplasm]
Inferred From
Npas4 stimulates Plk2 gene expression (Mus musculus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-15)
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