Reactome | USP33 [cytosol]

USP33 [cytosol]

Stable Identifier

R-HSA-5696962

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase 33 ecNumber3.4.19.12/ecNumber, UBP33_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9P0L0 VAPA

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        USP33 deubiquitinates ROBO1 (Homo sapiens)
        
        USP33 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TEY7 USP33

Gene Names

USP33, KIAA1097, VDU1

Chain

chain:1-942

Reference Genes

BioGPS Gene:23032 USP33

COSMIC - genes:USP33 USP33

CTD Gene:23032 USP33

dbSNP Gene:23032 USP33

ENSEMBL:ENSG00000077254 USP33

HGNC:20059 USP33

KEGG:hsa:23032 USP33

Monarch:23032 USP33

NCBI Gene:23032 USP33

OMIM:615146 USP33

UCSC:Q8TEY7 USP33

Reference Transcript

Other Identifiers

11718469_s_at

11730069_a_at

16688708

212513_PM_s_at

212513_s_at

214843_PM_s_at

214843_s_at

23032

2419112

2419114

2419115

2419116

2419117

2419120

2419121

2419128

2419129

2419132

2419133

2419135

2419136

2419137

2419139

2419140

2419141

2419142

2419144

2419145

2419146

2419147

2419148

2419149

2419150

2419152

2419154

2419155

2419156

2419157

2419158

2419159

2419160

2419162

2419163

2419164

2419165

2419166

2419167

2419168

2419172

2419173

33219_at

7917120

A_23_P106

A_24_P402495

A_24_P405190

GE53745

GO:0001664

GO:0004197

GO:0004843

GO:0005515

GO:0005654

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005925

GO:0006508

GO:0006511

GO:0006897

GO:0007399

GO:0007411

GO:0008233

GO:0008234

GO:0008270

GO:0008277

GO:0016192

GO:0016477

GO:0016579

GO:0016787

GO:0030891

GO:0031267

GO:0043025

GO:0046872

GO:0048471

GO:0048856

GO:0048870

GO:0050821

GO:0051298

GO:0070536

GO:0071108

GO:2000786

HMNXSV003014457

Hs.173694.0.S1_3p_a_at

Hs.173694.2.S1_3p_a_at

Hs.173694.2.S1_3p_at

Hs.173694.2.S1_3p_x_at

ILMN_1723536

ILMN_2306077

PH_hs_0010408

TC01002800.hg

Participates

as a component of

as a member of

USP20,USP33 [cytosol] (Homo sapiens)

Inferred To

Usp33 [cytosol] (Rattus norvegicus)

Usp20-33 [cytosol] (Drosophila melanogaster)

USP33 [cytosol] (Bos taurus)

USP33 [cytosol] (Canis familiaris)

USP33 [cytosol] (Danio rerio)

USP33 [cytosol] (Gallus gallus)

USP33 [cytosol] (Mus musculus)

USP33 [cytosol] (Sus scrofa)

USP33 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_963918.1, NP_963920.1, NP_055832.3

ENSEMBL

ENSG00000077254, ENST00000357428, ENSP00000359829, ENSP00000350009, ENST00000370793, ENSP00000359828, ENST00000370794, ENST00000370792, ENSP00000359830

OpenTargets

ENSG00000077254

GeneCards

USP33

HPA

ENSG00000077254-USP33

PRO

Q8TEY7

Pharos - Targets

Q8TEY7

HMDB Protein

HMDBP10114

PDB

2UZG

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99767 APBA2	1	APBA2 [cytosol] (R-HSA-6794245)	0.656	9
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.602	9
UniProt:Q9Y6N7 ROBO1	3	ROBO1 [plasma membrane] (R-HSA-204361) PolyUb-ROBO1 [plasma membrane] (R-HSA-8986095) p-Y1073-ROBO1 [plasma membrane] (R-HSA-375979)	0.564	3
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.527	4
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.527	2
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.527	3
UniProt:Q9H0I9 TKTL2			0.527	2
UniProt:O60478 G137B			0.524	2
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.508	2

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