SORD tetramer oxidizes xylitol to D-xylulose

Stable Identifier
R-HSA-5662471
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
xylitol + NAD+ => D-xylulose + NADH + H+
Locations in the PathwayBrowser
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Tetrameric sorbitol dehydrogenase (SORD tetramer) catalyzes the NAD-dependent oxidation of xylitol to form D-xylulose (Alvarez et al. 1993; Karlsson et al. 1989; Maret & Auld 1988; Pauly et al. 2003).

Literature References
PubMed ID Title Journal Year
2691249 Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme

Karlsson, C, Maret, W, Auld, DS, Höög, JO, Jörnvall, H

Eur. J. Biochem. 1989
12962626 X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase

Pauly, TA, Ekstrom, JL, Beebe, DA, Chrunyk, B, Cunningham, D, Griffor, M, Kamath, A, Lee, SE, Madura, R, Mcguire, D, Subashi, T, Wasilko, D, Watts, P, Mylari, BL, Oates, PJ, Adams, PD, Rath, VL

Structure 2003
8487505 Membrane-bound sorbitol dehydrogenase in human red blood cells. Studies in normal subjects and in enzyme-deficient subjects with congenital cataracts

Alvarez, A, Martínez, A, Ibarra, B, Medina, C, Bracamontes, M, Perea, J, Vaca, G

J. Inherit. Metab. Dis. 1993
3365415 Purification and characterization of human liver sorbitol dehydrogenase

Maret, W, Auld, DS

Biochemistry 1988
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
D-xylulose reductase activity of SORD tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created