Formation of xylulose-5-phosphate

Stable Identifier
R-HSA-5661270
Type
Pathway
Species
Homo sapiens
Synonyms
Catabolism of glucuronate to xylulose-5-phosphate
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Formation of xylulose-5-phosphate
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The conversion of D-glucuronate to D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, proceeds via L-gulonate, 3-dehydro-L-gulonate, L-xylulose, xylitol, and D-xylulose (Wamelink et al. 2008). D-glucuronate can be generated via the degradation of glucuronidated proteins. This pathway would have the effect of returning it to the pentose phosphate pathway or glycolysis.

Literature References
PubMed ID Title Journal Year
18987987 The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review

Wamelink, MM, Struys, EA, Jakobs, C

J Inherit Metab Dis 2008
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
glucuronate catabolic process to xylulose 5-phosphate (0019640)
Orthologous Events
Formation of xylulose-5-phosphate (Bos taurus)
Formation of xylulose-5-phosphate (Caenorhabditis elegans)
Formation of xylulose-5-phosphate (Canis familiaris)
Formation of xylulose-5-phosphate (Danio rerio)
Formation of xylulose-5-phosphate (Drosophila melanogaster)
Formation of xylulose-5-phosphate (Gallus gallus)
Formation of xylulose-5-phosphate (Mus musculus)
Formation of xylulose-5-phosphate (Rattus norvegicus)
Formation of xylulose-5-phosphate (Saccharomyces cerevisiae)
Formation of xylulose-5-phosphate (Schizosaccharomyces pombe)
Formation of xylulose-5-phosphate (Sus scrofa)
Formation of xylulose-5-phosphate (Xenopus tropicalis)
Authored
D'Eustachio, P  (2015-08-14)
Reviewed
Jassal, B  (2015-08-14)
Created
D'Eustachio, P  (2015-01-10)