CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate

Stable Identifier
R-HSA-5661290
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
L-gulonate + NAD+ => 3-dehydro-L-gulonate + NADH + H+
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Cytosolic CRYL1 (lambda-crystallin homolog, also known as L-gulonate 3-dehydrogenase) dimer catalyzes the NAD-dependent dehydrogenation of L-gulonate to form 3-dehydro-L-gulonate. The CRYL1 protein also functions as a lens crystallin, hence its name (Ishikura et al. 2005).

Literature References
PubMed ID Title Journal Year
15809331 Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase

Ishikura, S, Usami, N, Araki, M, Hara, A

J. Biochem. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
L-gulonate 3-dehydrogenase activity of CRYL1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created