CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate

Stable Identifier
R-HSA-5661290
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
L-gulonate + NAD+ => 3-dehydro-L-gulonate + NADH + H+
ReviewStatus
5/5
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CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate
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Cytosolic CRYL1 (lambda-crystallin homolog, also known as L-gulonate 3-dehydrogenase) dimer catalyzes the NAD-dependent dehydrogenation of L-gulonate to form 3-dehydro-L-gulonate. The CRYL1 protein also functions as a lens crystallin, hence its name (Ishikura et al. 2005).

Literature References
PubMed ID Title Journal Year
15809331 Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase

Araki, M, Hara, A, Usami, N, Ishikura, S

J. Biochem. 2005
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Catalyst Activity

L-gulonate 3-dehydrogenase activity of CRYL1 dimer [cytosol]

Physical Entity
CRYL1 dimer [cytosol] (Homo sapiens)
Activity
L-gulonate 3-dehydrogenase activity (GO:0050104)
Orthologous Events
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Bos taurus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Canis familiaris)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Drosophila melanogaster)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Gallus gallus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Mus musculus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Rattus norvegicus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Sus scrofa)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2015-08-14)
Reviewed
Jassal, B  (2015-08-14)
Created
D'Eustachio, P  (2015-01-10)
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