CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate

Stable Identifier
R-HSA-5661290
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Synonyms
L-gulonate + NAD+ => 3-dehydro-L-gulonate + NADH + H+
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic CRYL1 (lambda-crystallin homolog, also known as L-gulonate 3-dehydrogenase) dimer catalyzes the NAD-dependent dehydrogenation of L-gulonate to form 3-dehydro-L-gulonate. The CRYL1 protein also functions as a lens crystallin, hence its name (Ishikura et al. 2005).

Literature References
PubMed ID Title Journal Year
15809331 Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase

Araki, M, Hara, A, Usami, N, Ishikura, S

J. Biochem. 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

L-gulonate 3-dehydrogenase activity of CRYL1 dimer [cytosol]

Physical Entity
CRYL1 dimer [cytosol] (Homo sapiens)
Activity
L-gulonate 3-dehydrogenase activity (GO:0050104)
Orthologous Events
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Canis familiaris)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Drosophila melanogaster)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Gallus gallus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Mus musculus)
CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Rattus norvegicus)
Cross References
Rhea
Authored
D'Eustachio, P  (2015-08-13)
Reviewed
Jassal, B  (2015-08-13)
Created
D'Eustachio, P  (2015-01-09)
Cite Us!