NEIL1 recognizes and binds FapyG-dsDNA

Stable Identifier
R-HSA-5649657
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL1 recognizes and binds FapyG-dsDNA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NEIL1 (endonuclease 8-like protein 1) recognizes guanine derivative FapyG (Hazra et al. 2002). FapyG stands for 2,6-diamino-4-hydroxy-5-formamidopyrimidine, a ring-opened lesion that forms when hydroxyl radicals attack guanine, followed by one-electron reduction of the hydroxyl adduct radicals (Evans et al. 2004).
Literature References
PubMed ID Title Journal Year
11904416 Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, TK, Izumi, T, Boldogh, I, Imhoff, B, Kow, YW, Jaruga, P, Dizdaroglu, M, Mitra, S

Proc. Natl. Acad. Sci. U.S.A. 2002
15341901 Oxidative DNA damage and disease: induction, repair and significance

Evans, MD, Dizdaroglu, M, Cooke, MS

Mutat. Res. 2004
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Authored
Orlic-Milacic, M  (2014-12-04)
Reviewed
Borowiec, JA  (2014-12-22)
Sampath, H  (2019-01-03)
Created
Orlic-Milacic, M  (2014-11-21)
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