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Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Stable Identifier
R-HSA-110328
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depyrimidination (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
General
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SBGN
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Base excision repair is initiated by a DNA glycosylase which first recognizes and removes a damaged or incorrect (e.g. mismatched) base (Sokhansanj et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
11937636
A quantitative model of human DNA base excision repair. I. Mechanistic insights
Fitch, JP
,
Sokhansanj, BA
,
Rodrigue, GR
,
Wilson DM, 3rd
Nucleic Acids Res
2002
Participants
Events
UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine
(Homo sapiens)
UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine
(Homo sapiens)
TDG glycosylase mediated recognition and binding of an ethenocytosine
(Homo sapiens)
TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine
(Homo sapiens)
TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine
(Homo sapiens)
SMUG1 glycosylase mediated recognition and binding of uracil in DNA
(Homo sapiens)
MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences
(Homo sapiens)
MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences
(Homo sapiens)
NTHL1 glycosylase mediated recognition and binding of cytosine glycol
(Homo sapiens)
NTHL1 glycosylase mediated recognition and binding of dihydrouracil
(Homo sapiens)
NTHL1 glycosylase mediated recognition and binding of formamidopyrimidine (FapyA)
(Homo sapiens)
NTHL1 glycosylase mediated recognition and binding of thymine glycol
(Homo sapiens)
OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG)
(Homo sapiens)
NEIL1 translocates to the nucleus
(Homo sapiens)
NEIL1 recognizes and binds DHU-dsDNA
(Homo sapiens)
NEIL1 recognizes and binds FapyA-dsDNA
(Homo sapiens)
NEIL1 recognizes and binds FapyG-dsDNA
(Homo sapiens)
NEIL1 recognizes and binds thymine glycol
(Homo sapiens)
NEIL2 recognizes and binds 5-OHU-dsDNA
(Homo sapiens)
NEIL3 recognizes and binds to thymine glycol in telomeric DNA
(Homo sapiens)
NEIL3 recognizes and binds to thymine glycol
(Homo sapiens)
Participates
as an event of
Depyrimidination (Homo sapiens)
Event Information
Go Biological Process
depyrimidination (0045008)
Orthologous Events
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Bos taurus)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Canis familiaris)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Danio rerio)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Gallus gallus)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Mus musculus)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Rattus norvegicus)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Sus scrofa)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Xenopus tropicalis)
Authored
Matthews, L (2004-02-03)
Reviewed
Borowiec, JA (2014-12-22)
Created
Matthews, L (2004-01-29)
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