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NEIL1 [nucleoplasm]
Stable Identifier
R-HSA-5649648
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Endonuclease 8-like 1, DNA glycosylase/AP lyase Neil1, NEH1
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
NEIL1 cleaves DHU from damaged DNA (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:DHU-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1 cleaves FapyA from damaged DNA (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:FapyA-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1 cleaves FapyG from damaged DNA (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:FapyG-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1 cleaves thymine glycol from damaged DNA (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:Tg-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
NEIL1 recognizes and binds DHU-dsDNA (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:DHU-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1 recognizes and binds FapyA-dsDNA (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:FapyA-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1 recognizes and binds FapyG-dsDNA (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:FapyG-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1 recognizes and binds thymine glycol (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:Tg-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1 translocates to the nucleus (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 incises DNA strand 5' to the AP site (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 recruits POLB to incised AP site (Homo sapiens)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Homo sapiens)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
NEIL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96FI4 NEIL1
Gene Names
NEIL1
Chain
initiator methionine:, chain:2-390
Reference Genes
BioGPS Gene:79661 NEIL1
COSMIC (genes):NEIL1 NEIL1
CTD Gene:79661 NEIL1
dbSNP Gene:79661 NEIL1
ENSEMBL:ENSG00000140398 NEIL1
HGNC:18448 NEIL1
Monarch:79661 NEIL1
NCBI Gene:79661 NEIL1
OMIM:608844 NEIL1
UCSC:Q96FI4 NEIL1
Reference Transcript
RefSeq:XM_005254659.4 NEIL1
RefSeq:XM_011522003.2 NEIL1
RefSeq:XM_011522004.2 NEIL1
RefSeq:XM_006720680.1 NEIL1
RefSeq:NM_001256552.1 NEIL1
RefSeq:XM_011522002.1 NEIL1
RefSeq:XM_006720681.1 NEIL1
RefSeq:NM_024608.3 NEIL1
Other Identifiers
11754518_a_at
16803197
219396_PM_s_at
219396_s_at
241477_PM_at
241477_at
3602300
3602301
3602302
3602303
3602304
3602305
3602306
3602307
3602308
3602309
3602310
3602312
3602313
3602314
3602315
3602316
3602317
3602318
3602319
3602320
3602321
3602322
3602323
3602324
3602325
3602326
3602327
3602328
3602329
3602330
3602331
3602332
3602333
3602334
3602335
44133_at
79661
7985001
A_14_P121702
A_23_P129157
GE88646
GO:0003676
GO:0003677
GO:0003684
GO:0003824
GO:0003906
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006281
GO:0006284
GO:0006287
GO:0006979
GO:0008270
GO:0016787
GO:0016798
GO:0016799
GO:0016829
GO:0019104
GO:0032074
GO:0043226
GO:0045008
GO:0055086
GO:0140078
GO:0140097
GO:1901135
HMNXSV003043792
HMNXSV003049639
Hs.258515.0.A1_3p_at
ILMN_1812622
PH_hs_0026837
TC15000695.hg
g13375816_3p_s_at
Participates
as a member of
NEIL1,NEIL2 [nucleoplasm] (Homo sapiens)
as an input of
NEIL1 recognizes and binds FapyA-dsDNA (Homo sapiens)
NEIL1 recognizes and binds FapyG-dsDNA (Homo sapiens)
NEIL1 recognizes and binds thymine glycol (Homo sapiens)
NEIL1 recognizes and binds DHU-dsDNA (Homo sapiens)
as a component of
NEIL1:FapyA-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1:FapyG-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1:Tg-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1:DHU-dsDNA [nucleoplasm] (Homo sapiens)
as an output of
NEIL1 translocates to the nucleus (Homo sapiens)
Other forms of this molecule
NEIL1 [cytosol]
NEIL1 G83D [nucleoplasm]
NEIL1 E28del [nucleoplasm]
NEIL1 Q282* [cytosol]
Inferred To
neil1 [nucleoplasm]
(Danio rerio)
neil1 [nucleoplasm]
(Xenopus tropicalis)
NEIL1 [nucleoplasm]
(Bos taurus)
NEIL1 [nucleoplasm]
(Canis familiaris)
NEIL1 [nucleoplasm]
(Gallus gallus)
NEIL1 [nucleoplasm]
(Mus musculus)
NEIL1 [nucleoplasm]
(Sus scrofa)
Neil1 [nucleoplasm]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000140398
ENSEMBL
ENSP00000455730
,
ENST00000569035
,
ENSP00000457352
,
ENST00000564784
,
ENSP00000347170
,
ENST00000355059
IntEnz
4.2.99.18
HPA
ENSG00000140398-NEIL1
PRO
Q96FI4
Pharos - Targets
Q96FI4
PDB
1TDH
,
8FTJ
,
5ITT
,
5ITU
,
6LWP
,
6LWO
,
6LWH
,
6LWG
,
5ITR
,
6LWN
,
6LWF
,
5ITX
,
5ITY
,
6LWM
,
6LWR
,
6LWQ
,
5ITQ
,
7TMX
,
6LWC
,
6LWK
,
6LWD
,
6LWL
,
6LWA
,
6LWB
,
6LWJ
,
6LWI
,
4NRV
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