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p-T389-RPS6KB1-2 [cytosol]
Stable Identifier
R-HSA-9975791
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p70 S6K1-P
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Phosphorylation and activation of eIF4B by activated S6K1 (Homo sapiens)
p-T389/412-RPS6KB1 [cytosol] (Homo sapiens)
p-T389-RPS6KB1-2 [cytosol] (Homo sapiens)
Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)
p-T389/412-RPS6KB1 [cytosol] (Homo sapiens)
p-T389-RPS6KB1-2 [cytosol] (Homo sapiens)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Homo sapiens)
p-T389/412-RPS6KB1 [cytosol] (Homo sapiens)
p-T389-RPS6KB1-2 [cytosol] (Homo sapiens)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Homo sapiens)
p-T389/412-RPS6KB1 [cytosol] (Homo sapiens)
p-T389-RPS6KB1-2 [cytosol] (Homo sapiens)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
p-T389/412-RPS6KB1 [cytosol] (Homo sapiens)
p-T389-RPS6KB1-2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23443-2 RPS6KB1
Gene Names
RPS6KB1, STK14A
Participates
as a member of
p-T389/412-RPS6KB1 [cytosol] (Homo sapiens)
Other forms of this molecule
RPS6KB1-2 [cytosol]
Inferred To
phospho-RPS6KB1 [cytosol]
(Canis familiaris)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Bos taurus)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Caenorhabditis elegans)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Danio rerio)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Dictyostelium discoideum)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Drosophila melanogaster)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Gallus gallus)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Mus musculus)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Rattus norvegicus)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Sus scrofa)
phospho-p-T389-RPS6KB1-2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 389
Coordinate
389
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001258989.1
,
NP_001258971.1
,
NP_001258972.1
,
NP_001258973.1
,
NP_003152.1
ZINC - World Drugs
KS6B1_HUMAN
Guide to Pharmacology - Targets
1525
OpenTargets
ENSG00000108443
ENSEMBL
ENSP00000441993
,
ENST00000393021
,
ENSP00000384335
,
ENSP00000225577
,
ENSP00000376744
,
ENST00000406116
,
ENST00000225577
,
ENSG00000108443
,
ENST00000443572
ZINC - FDA approved
KS6B1_HUMAN
ZINC - Substances
KS6B1_HUMAN
ZINC - Biogenic
KS6B1_HUMAN
ZINC target
P23443
PRO
P23443
GlyGen
P23443
PDB
4L3L
,
4RLO
,
3A60
,
3WF6
,
4L46
,
3A62
,
3WF7
,
5WBK
,
4L45
,
3WE4
,
3A61
,
4L44
,
7N93
,
5WBH
,
4RLP
,
3WF5
,
4L3J
,
3WF9
,
4L43
,
4L42
,
7N91
,
3WF8
ZINC - Investigational
KS6B1_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000108443-RPS6KB1
GeneCards
RPS6KB1
Pharos - Targets
P23443
ZINC - Predictions - Purchasable
KS6B1_HUMAN
HMDB Protein
HMDBP01426
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.64
3
UniProt:Q13057 COASY
1
COASY [mitochondrial outer membrane]
(R-HSA-196735)
0.544
4
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