Reactome | ELOVL5 [endoplasmic reticulum membrane]

ELOVL5 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-548679

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Elongation of very long chain fatty acids protein 5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
        
        ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex (Homo sapiens)
        
        ELOVL5 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYP7 ELOVL5

Gene Names

ELOVL5, ELOVL2, PRO0530

Chain

chain:1-299

Reference Genes

BioGPS Gene:60481 ELOVL5

COSMIC (genes):ELOVL2 ELOVL5

COSMIC (genes):ELOVL5 ELOVL5

CTD Gene:60481 ELOVL5

dbSNP Gene:60481 ELOVL5

ENSEMBL:ENSG00000012660 ELOVL5

HGNC:21308 ELOVL5

KEGG:hsa:60481 ELOVL5

Monarch:60481 ELOVL5

NCBI Gene:60481 ELOVL5

OMIM:611805 ELOVL5

UCSC:Q9NYP7 ELOVL5

Reference Transcript

Other Identifiers

11716078_a_at

11757300_s_at

17020152

208788_PM_at

208788_at

215082_PM_at

215082_at

2957606

2957607

2957608

2957609

2957611

2957613

2957614

2957615

2957617

2957618

2957621

2957626

2957628

2957629

2957631

2957634

2957635

2957636

2957661

33821_at

35117_at

60481

8127145

A_19_P00330212

A_23_P156497

A_23_P431521

A_33_P3273719

GE62983

GE874610

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0006633

GO:0006636

GO:0006790

GO:0009922

GO:0016020

GO:0016740

GO:0019367

GO:0030148

GO:0030425

GO:0030497

GO:0034625

GO:0034626

GO:0035338

GO:0036109

GO:0042761

GO:0042995

GO:0043025

GO:0043226

GO:0043651

GO:0045723

GO:0055086

GO:0097447

GO:1901135

HMNXSV003041468

HMNXSV003050758

Hs.305989.0.S1_3p_at

Hs2.384938.1.S1_3p_s_at

ILMN_2174369

PH_hs_0023892

TC06001813.hg

g12053372_3p_at

Participates

as a member of

as an output of

ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex (Homo sapiens)

Inferred To

ELOVL5 [endoplasmic reticulum membrane] (Bos taurus)

ELOVL5 [endoplasmic reticulum membrane] (Canis familiaris)

ELOVL5 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

ELOVL5 [endoplasmic reticulum membrane] (Gallus gallus)

ELOVL5 [endoplasmic reticulum membrane] (Sus scrofa)

Elo68alpha [endoplasmic reticulum membrane] (Drosophila melanogaster)

Elo68beta [endoplasmic reticulum membrane] (Drosophila melanogaster)

Elovl5 [endoplasmic reticulum membrane] (Mus musculus)

Elovl5 [endoplasmic reticulum membrane] (Rattus norvegicus)

elovl5 [endoplasmic reticulum membrane] (Danio rerio)

elovl5 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Homologues of ELOVL5 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

Homologues of ELOVL5 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000012660

ENSEMBL

ENSP00000359951, ENST00000304434, ENST00000370913, ENST00000370918, ENSP00000306640, ENSP00000359956

IntEnz

2.3.1.199

HPA

ENSG00000012660-ELOVL5

ZINC - Substances

ELOV5_HUMAN

ZINC target

Q9NYP7

PRO

Q9NYP7

Pharos - Targets

Q9NYP7

Orphanet

ELOVL5

GlyGen

Q9NYP7

HMDB Protein

HMDBP11728

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.556	3
UniProt:Q9NZG7 NINJ2			0.556	3
UniProt:P09601 HMOX1	4	HMOX1 [cytosol] (R-HSA-9609901) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [nucleoplasm] (R-HSA-9708567)	0.556	3
UniProt:Q9UPZ6 THSD7A	3	THSD7A [endoplasmic reticulum lumen] (R-HSA-5173009) glc-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173197) O-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173184)	0.556	3
UniProt:P57105 SYJ2B			0.556	3
UniProt:A0AVG3 A0AVG3			0.556	3
UniProt:O14523 C2C2L			0.556	3
UniProt:O15400 STX7			0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.556	3
UniProt:P30519 HMOX2	3	HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [plasma membrane] (R-HSA-6799676)	0.556	3
UniProt:Q8N2H4 SYS1	1	SYS1 [trans-Golgi network membrane] (R-HSA-6813921)	0.556	3
UniProt:Q9BU79 TM243			0.556	3
UniProt:Q04941 PLP2			0.556	3
UniProt:Q9NUM3 S39A9			0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:Q8IVM8 S22A9			0.527	2
UniProt:P16444 DPEP1	1	DPEP1 [plasma membrane] (R-HSA-2142820)	0.527	2

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