ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex

Stable Identifier
R-HSA-9854142
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on a mouse model of hepatic steatosis, expression of the ELOVL5 gene, encoding Elongation of very long chain fatty acids protein 5 that localizes to the endoplasmic reticulum membrane, is directly stimulated by PPARG2 and the KMT2D (MLL4) complex (Kim et al. 2016). Elovl5 gene expression is reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA seq, supplementary information).
Literature References
PubMed ID Title Journal Year
27806304 Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARĪ³2

Kim, DH, Sandhu, J, Kwon, JS, Lee, JW, Lee, SK, Tontonoz, P, Lee, S, Kim, J

Cell Rep 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
Activated p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] (Homo sapiens)
Inferred From
Elovl5 gene expression is stimulated by Pparg2:Rxra and Mll4,(Mll3) complex (Mus musculus)
Authored
Orlic-Milacic, M  (2023-11-22)
Created
Orlic-Milacic, M  (2023-11-22)
Cite Us!