Reactome | DPEP1 [plasma membrane]

DPEP1 [plasma membrane]

Stable Identifier

R-HSA-2142820

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dipeptidase 1, DPEP1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        LTC4-CYSLTR mediated IL4 production (Homo sapiens)
        
        LTD4 is converted to LTE4 by DPEP1/2 (Homo sapiens)
        
        DPEP1,2 dimers [plasma membrane] (Homo sapiens)
        
        DPEP1 dimer [plasma membrane] (Homo sapiens)
        
        DPEP1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16444 DPEP1

Gene Names

DPEP1, MDP, RDP

Chain

signal peptide:1-16, chain:17-385, propeptide:386-411

Reference Genes

BioGPS Gene:1800 DPEP1

COSMIC (genes):DPEP1 DPEP1

CTD Gene:1800 DPEP1

dbSNP Gene:1800 DPEP1

ENSEMBL:ENSG00000015413 DPEP1

HGNC:3002 DPEP1

Monarch:1800 DPEP1

NCBI Gene:1800 DPEP1

OMIM:179780 DPEP1

UCSC:P16444 DPEP1

Reference Transcript

Other Identifiers

11756343_a_at

11763828_a_at

16822035

1800

205983_PM_at

205983_at

3674250

3674251

3674252

3674253

3674254

3674256

3674257

3674258

3674259

3674260

3674261

3674262

3674263

3674264

3674265

3674266

3674267

3674268

37413_at

7997962

A_23_P152262

GE61043

GO:0002376

GO:0003824

GO:0005515

GO:0005615

GO:0005654

GO:0005886

GO:0006508

GO:0006520

GO:0006575

GO:0006629

GO:0006691

GO:0006749

GO:0006751

GO:0006790

GO:0006954

GO:0008235

GO:0008237

GO:0008270

GO:0008289

GO:0008800

GO:0016020

GO:0016324

GO:0016787

GO:0016805

GO:0016999

GO:0030054

GO:0030336

GO:0030593

GO:0031528

GO:0034235

GO:0042995

GO:0043027

GO:0043066

GO:0043154

GO:0043226

GO:0045177

GO:0046872

GO:0048870

GO:0050667

GO:0070062

GO:0070573

GO:0071277

GO:0071466

GO:0071732

GO:0072340

GO:0072341

GO:0098552

GO:0098772

GO:0140096

GO:1901749

HMNXSV003001161

ILMN_1670779

J05257_at

PH_hs_0000017

TC16000701.hg

g4758189_3p_at

g4758189_3p_x_at

Participates

as a component of

DPEP1 dimer [plasma membrane] (Homo sapiens)

Inferred To

Homologues of DPEP1 [plasma membrane] (Sus scrofa)

CG5917 [plasma membrane] (Drosophila melanogaster)

DPEP1 [plasma membrane] (Bos taurus)

DPEP1 [plasma membrane] (Canis familiaris)

DPEP1 [plasma membrane] (Gallus gallus)

DPEP1 [plasma membrane] (Mus musculus)

DPEP1 [plasma membrane] (Rattus norvegicus)

DPEP1 [plasma membrane] (Schizosaccharomyces pombe)

DPEP1 [plasma membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

1393

OpenTargets

ENSG00000015413

ENSEMBL

ENSP00000397313, ENST00000690203, ENSP00000261615, ENST00000393092, ENSP00000508584, ENST00000261615, ENST00000421184, ENSP00000376807

ZINC - Substances

DPEP1_HUMAN

ZINC target

P16444

PRO

P16444

GlyGen

P16444

PDB

1ITU, 1ITQ

IntEnz

3.5.2.6

HPA

ENSG00000015413-DPEP1

Pharos - Targets

P16444

ZINC - Predictions - Purchasable

DPEP1_HUMAN

HMDB Protein

HMDBP02684

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TAD4 SLC30A5	2	SLC30A5 [secretory granule membrane] (R-HSA-437105) SLC30A5 [Golgi membrane] (R-HSA-9817559)	0.527	2
UniProt:P17302 GJA1	7	GJA1 [Golgi-associated vesicle membrane] (R-HSA-190544) GJA1 [plasma membrane] (R-HSA-158058) p-Y265-GJA1 [plasma membrane] (R-HSA-191657) GJA1 [lysosomal membrane] (R-HSA-196173) GJA1 [endoplasmic reticulum membrane] (R-HSA-190654) GJA1 [Golgi membrane] (R-HSA-190649) p-S373-GJA1 [plasma membrane] (R-HSA-9857671)	0.527	2
UniProt:Q9NYP7 ELOVL5	1	ELOVL5 [endoplasmic reticulum membrane] (R-HSA-548679)	0.527	2
UniProt:Q9Y672 ALG6	3	ALG6 A333V [endoplasmic reticulum membrane] (R-HSA-4724295) ALG6 S478P [endoplasmic reticulum membrane] (R-HSA-4724296) ALG6 [endoplasmic reticulum membrane] (R-HSA-449645)	0.527	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.527	2
UniProt:Q8TC12 RDH11	1	RDH11 [endoplasmic reticulum membrane] (R-HSA-975645)	0.527	3
UniProt:Q9BVK2 ALG8	5	ALG8 G275D [endoplasmic reticulum membrane] (R-HSA-4724304) ALG8 T47P [endoplasmic reticulum membrane] (R-HSA-4724334) ALG8 V133Sfs3 [endoplasmic reticulum membrane] (R-HSA-4724313) ALG8 T138Kfs19 [endoplasmic reticulum membrane] (R-HSA-4724312) ALG8 [endoplasmic reticulum membrane] (R-HSA-449640)	0.527	2
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.527	3
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.527	3
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.527	2
UniProt:O94901 SUN1	1	SUN1 [nuclear envelope] (R-HSA-912371)	0.527	3