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SYS1 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6813921
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Protein SYS1 homolog
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
ARFRP1 recruits ARL1 to the TGN (Homo sapiens)
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
ARL1 recruits TGN Golgin homodimers (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP [trans-Golgi network membrane] (Homo sapiens)
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 binds AcM-ARFRP1 (Homo sapiens)
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
SYS1 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N2H4 SYS1
Gene Names
SYS1, C20orf169
Chain
chain:1-156
Reference Genes
BioGPS Gene:90196 SYS1
COSMIC (genes):SYS1 SYS1
CTD Gene:90196 SYS1
dbSNP Gene:90196 SYS1
ENSEMBL:ENSG00000204070 SYS1
ENSEMBL_homo_sapiens_GENE:ENSG00000204070.10 SYS1
HGNC:16162 SYS1
KEGG Gene (Homo sapiens):90196 SYS1
Monarch:90196 SYS1
NCBI Gene:90196 SYS1
OMIM:612979 SYS1
UCSC:Q8N2H4 SYS1
Reference Transcript
RefSeq:NM_033542.3 SYS1
RefSeq:NM_001197129.1 SYS1
RefSeq:NM_001099791.2 SYS1
Other Identifiers
11719557_at
11719558_at
224668_PM_at
224668_at
224669_PM_at
224669_at
224670_PM_at
224670_at
238470_PM_at
238470_at
3886843
3886844
3886845
3886848
3886849
3886850
3886851
3886852
3886854
3886855
3886856
3886857
3886858
3886859
3886860
3886865
44144_at
58922_s_at
65625_r_at
78868_at
8062964
90196
90803_at
A_14_P100826
A_14_P112267
A_21_P0000004
A_23_P369456
A_33_P3398107
GO:0000139
GO:0005515
GO:0005794
GO:0005802
GO:0005829
GO:0006895
GO:0015031
GO:0016020
GO:0016192
GO:0032588
GO:0034067
GO:0043001
GO:0043226
GO:0072659
HMNXSV003005692
HMNXSV003050544
Hs.302810.0.S1_3p_at
Hs.302810.0.S2_3p_at
Hs.302810.0.S2_3p_x_at
Hs.302810.0.S3_3p_at
Hs.318469.0.A1_3p_at
ILMN_1756590
PH_hs_0023279
TC20001238.hg
TC20001731.hg
Participates
as an input of
SYS1 binds AcM-ARFRP1 (Homo sapiens)
as a component of
AcM-ARFRP1:GTP:SYS1 [trans-Golgi network membrane] (Homo sapiens)
Inferred To
sys1 [trans-Golgi network membrane]
(Dictyostelium discoideum)
sys1 [trans-Golgi network membrane]
(Xenopus tropicalis)
SYS1 [trans-Golgi network membrane]
(Bos taurus)
SYS1 [trans-Golgi network membrane]
(Caenorhabditis elegans)
SYS1 [trans-Golgi network membrane]
(Canis familiaris)
SYS1 [trans-Golgi network membrane]
(Gallus gallus)
SYS1 [trans-Golgi network membrane]
(Plasmodium falciparum)
SYS1 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
SYS1 [trans-Golgi network membrane]
(Sus scrofa)
Sys1 [trans-Golgi network membrane]
(Drosophila melanogaster)
Sys1 [trans-Golgi network membrane]
(Mus musculus)
Sys1 [trans-Golgi network membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_291020.1
,
NP_001093261.1
,
NP_001184058.1
OpenTargets
ENSG00000204070
GeneCards
Q8N2H4
HPA
ENSG00000204070-SYS1
Ensembl
ENSP00000361812
,
ENSP00000416506
,
ENSP00000243918
,
ENSG00000204070
,
ENST00000243918
,
ENST00000372727
,
ENST00000426004
PRO
Q8N2H4
Pharos - Targets
Q8N2H4
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6UXG8-3 Q6UXG83
0.556
3
IntAct:EBI-23641393 CCSB ORF ID
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q8NI22 MCFD2
3
MCFD2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689836)
MCFD2 [ER to Golgi transport vesicle membrane]
(R-HSA-1017216)
MCFD2 [endoplasmic reticulum membrane]
(R-HSA-5689470)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:P15151 PVR
1
PVR [plasma membrane]
(R-HSA-420600)
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:Q8IWU4 SLC30A8
2
SLC30A8 [Golgi membrane]
(R-HSA-9817561)
SLC30A8 [secretory granule membrane]
(R-HSA-437106)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q9NYP7 ELOVL5
1
ELOVL5 [endoplasmic reticulum membrane]
(R-HSA-548679)
0.556
3
UniProt:P26951 IL3RA
1
IL3RA [plasma membrane]
(R-HSA-879938)
0.556
3
UniProt:Q9NQQ7-3 Q9NQQ73
0.556
3
IntAct:EBI-22589183 CCSB ORF ID
0.556
3
UniProt:Q8N743 KI3L3
0.556
3
UniProt:Q96DZ7 T4S19
0.556
3
UniProt:Q9Y676 MRPS18B
1
MRPS18B [mitochondrial inner membrane]
(R-HSA-5368234)
0.556
3
UniProt:O43557 TNFSF14
1
TNFSF14 [plasma membrane]
(R-HSA-5667149)
0.556
3
UniProt:O14880 MGST3
1
MGST3 [endoplasmic reticulum membrane]
(R-HSA-176053)
0.556
3
UniProt:Q9NWD8 TM248
0.556
3
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