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CYP2E1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-52681
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 2E1 , CYPIIE1, P450-J
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Paracetamol ADME (Homo sapiens)
CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP2C19 5-hydroxylates omeprazole (Homo sapiens)
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 reactions (Homo sapiens)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Benzene is hydroxylated to phenol (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Coumarin is 7-hydroxylated by CYP2A6 (Homo sapiens)
Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
O-atom dealkylation of dextromethorphan (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of maresins (Homo sapiens)
Biosynthesis of maresin-like SPMs (Homo sapiens)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05181 CYP2E1
Gene Names
CYP2E1, CYP2E
Chain
chain:1-493
Reference Genes
BioGPS Gene:1571 CYP2E1
COSMIC (genes):CYP2E1 CYP2E1
CTD Gene:1571 CYP2E1
dbSNP Gene:1571 CYP2E1
ENSEMBL:ENSG00000130649 CYP2E1
HGNC:2631 CYP2E1
Monarch:1571 CYP2E1
NCBI Gene:1571 CYP2E1
OMIM:124040 CYP2E1
UCSC:P05181 CYP2E1
Reference Transcript
RefSeq:NM_000773.3 CYP2E1
Other Identifiers
11731467_a_at
11731468_x_at
1431_PM_at
1431_at
1571
16711001
209975_3p_at
209975_PM_at
209975_at
209976_PM_s_at
209976_s_at
3272982
3272983
3272984
3272985
3272986
3272987
3272991
3272992
3272993
3272994
3272995
3272996
3272997
3272998
3273001
3273002
3273003
3273004
3273005
3273006
3273008
3273012
3273014
40379_at
75592_at
7931643
A_14_P114475
A_14_P131551
A_23_P98002
A_24_P394940
GE57463
GO:0001676
GO:0002933
GO:0003824
GO:0004497
GO:0005506
GO:0005737
GO:0005739
GO:0005743
GO:0005783
GO:0005789
GO:0006629
GO:0006631
GO:0006805
GO:0008202
GO:0008392
GO:0009617
GO:0016098
GO:0016491
GO:0016705
GO:0016709
GO:0016712
GO:0018601
GO:0018885
GO:0018910
GO:0018960
GO:0019373
GO:0019825
GO:0019899
GO:0020037
GO:0030544
GO:0042197
GO:0042759
GO:0043226
GO:0043231
GO:0046872
GO:0051879
GO:0070330
GO:0120319
HMNXSV003042818
ILMN_1665437
J02843_at
J02843cds_3p_s_at
PH_hs_0004282
TC10000956.hg
g6470140_3p_at
Participates
as a member of
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
CYP2E1 [endoplasmic reticulum membrane]
(Bos taurus)
CYP2E1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2E1 [endoplasmic reticulum membrane]
(Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane]
(Danio rerio)
CYP2E1 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CYP2E1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
CYP2E1 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP2E1 [endoplasmic reticulum membrane]
(Mus musculus)
CYP2E1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP2E1 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP2E1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
cyp-33e3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c12 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
daf-9 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2E1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2E1 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Homologues of CYP2E1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Homologues of CYP2E1 [endoplasmic reticulum membrane]
(Gallus gallus)
Cross References
Guide to Pharmacology - Targets
1330
ENSEMBL
ENST00000252945
,
ENSP00000252945
,
ENSP00000440689
,
ENST00000463117
OpenTargets
ENSG00000130649
ZINC - Substances
CP2E1_HUMAN
ZINC - Biogenic
CP2E1_HUMAN
ZINC target
P05181
PRO
P05181
PDB
3KOH
,
3GPH
,
3T3Z
,
3E6I
,
3LC4
,
3E4E
ZINC - Investigational
CP2E1_HUMAN
ZINC - Metabolites
CP2E1_HUMAN
HPA
ENSG00000130649-CYP2E1
Pharos - Targets
P05181
ZINC - Predictions - Purchasable
CP2E1_HUMAN
HMDB Protein
HMDBP01544
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96DB5 RMD1
0.527
2
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