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CYP2E1 [endoplasmic reticulum membrane]
Stable Identifier
R-CFA-52681
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
endoplasmic reticulum membrane
Synonyms
Q9MZY0
Locations in the PathwayBrowser
Expand all
Drug ADME (Canis familiaris)
Aspirin ADME (Canis familiaris)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Canis familiaris)
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Paracetamol ADME (Canis familiaris)
CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Xenobiotics (Canis familiaris)
CYP2D6 4-hydroxylates debrisoquine (Canis familiaris)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 reactions (Canis familiaris)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Canis familiaris)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Benzene is hydroxylated to phenol (Canis familiaris)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Dehalogenation of carbon tetrachloride to form a free radical (Canis familiaris)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Canis familiaris)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
MEOS oxidizes ethanol to acetaldehyde (Canis familiaris)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Canis familiaris)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
CYP2F1 dehydrogenates 3-methylindole (Canis familiaris)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Coumarin is 7-hydroxylated by CYP2A13 (Canis familiaris)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Coumarin is 7-hydroxylated by CYP2A6 (Canis familiaris)
Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Canis familiaris)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
O-atom dealkylation of dextromethorphan (Canis familiaris)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Biosynthesis of specialized proresolving mediators (SPMs) (Canis familiaris)
Biosynthesis of DHA-derived SPMs (Canis familiaris)
Biosynthesis of maresins (Canis familiaris)
Biosynthesis of maresin-like SPMs (Canis familiaris)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Canis familiaris)
CYP2E1 [endoplasmic reticulum membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:Q9MZY0
Reference Genes
BioGPS Gene:415128
ENSEMBL:ENSCAFG00030026254
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000013311.5
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030026254.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040018971.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845027431.1
KEGG Gene (Canis lupus familiaris):415128
Monarch:415128
NCBI Gene:415128
Reference Transcript
RefSeq:NM_001003339.1
Other Identifiers
415128
AFFX-Cf_P450-2E1_3_s_at
AFFX-Cf_P450-2E1_5_s_at
AFFX-Cf_P450-2E1_M_s_at
Cfa.648.1.S1_s_at
GO:0001676
GO:0002933
GO:0003824
GO:0004497
GO:0005506
GO:0006629
GO:0006805
GO:0008202
GO:0016098
GO:0016491
GO:0016705
GO:0016712
GO:0018601
GO:0018960
GO:0019899
GO:0020037
GO:0046483
GO:0120319
Participates
as a member of
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Canis familiaris)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Canis familiaris)
as a candidate of
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Canis familiaris)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Canis familiaris)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Canis familiaris)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Canis familiaris)
Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane] (Canis familiaris)
Inferred From
CYP2E1 [endoplasmic reticulum membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001003339.1
IntEnz
1.14.14.1
Ensembl
ENSCAFP00845037964
,
ENSCAFG00845027431
,
ENSCAFT00845048390
VGNC
50353
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