TTP:mRNA Complex [cytosol]

Stable Identifier
R-HSA-450365
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
18367721 Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation

Deleault, KM, Gross, RH, Townley-Tilson, WH, Brooks, SA, Emmons, J, Whitfield, ML, Skinner, SJ

RNA 2008
12324455 RNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein

Applegate, JL, Arseneau, KO, Pizarro, TT, Pelo, JW, Sachedina, MA, Worthington, MT

J Biol Chem 2002
15117938 RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs

Malicka, J, Wilson, GM, Brewer, BY, Blackshear, PJ

J Biol Chem 2004
12705825 Selective RNA binding by a single CCCH zinc-binding domain from Nup475 (Tristetraprolin)

Michel, SL, Berg, JM, Guerrerio, AL

Biochemistry 2003
12639954 Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates

Brewer, G, Guan, X, Zhou, P, Kennington, EA, Lai, WS, Wilson, GM, Blackshear, PJ

J Biol Chem 2003
10330172 Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA

Kennington, EA, Carballo, E, Lai, WS, Strum, JR, Phillips, RS, Blackshear, PJ

Mol Cell Biol 1999
Participants
components
Participates
as an input of
as a component of
as an output of
Inferred To
TTP:mRNA Complex [cytosol] (Bos taurus)
TTP:mRNA Complex [cytosol] (Caenorhabditis elegans)
TTP:mRNA Complex [cytosol] (Canis familiaris)
TTP:mRNA Complex [cytosol] (Dictyostelium discoideum)
TTP:mRNA Complex [cytosol] (Drosophila melanogaster)
TTP:mRNA Complex [cytosol] (Mus musculus)
TTP:mRNA Complex [cytosol] (Rattus norvegicus)
TTP:mRNA Complex [cytosol] (Saccharomyces cerevisiae)
TTP:mRNA Complex [cytosol] (Schizosaccharomyces pombe)
TTP:mRNA Complex [cytosol] (Sus scrofa)
TTP:mRNA Complex [cytosol] (Xenopus tropicalis)
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