Reactome | MK2 phosphorylates ZFP36 (Tristetraproline, TTP)

MK2 phosphorylates ZFP36 (Tristetraproline, TTP)

Stable Identifier

R-HSA-450463

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MK2 phosphorylates ZFP36 (Tristetraproline, TTP)

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TTP is phosphorylated by MK2 at serines 60 and 186.

Literature References

PubMed ID	Title	Journal	Year
18481987	Control of mRNA decay by phosphorylation of tristetraprolin Sandler, H, Stoecklin, G	Biochem Soc Trans	2008
14688255	MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding Chrestensen, CA, Schroeder, MJ, Shabanowitz, J, Hunt, DF, Pelo, JW, Worthington, MT, Sturgill, TW	J Biol Chem	2004
15014438	MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay Stoecklin, G, Stubbs, T, Kedersha, N, Wax, S, Rigby, WF, Blackwell, TK, Anderson, P	EMBO J	2004
15944294	Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function Rigby, WF, Roy, K, Collins, J, Rigby, S, Connolly, JE, Bloch, DB, Brooks, SA	J Immunol	2005
16262601	Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis Cao, H, Deterding, LJ, Venable, JD, Kennington, EA, Yates, JR 3rd, Tomer, KB, Blackshear, PJ	Biochem J	2006