Reactome | MK2 phosphorylates ZFP36 (Tristetraproline, TTP)

MK2 phosphorylates ZFP36 (Tristetraproline, TTP)

Stable Identifier

R-HSA-450463

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MK2 phosphorylates ZFP36 (Tristetraproline, TTP)

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TTP is phosphorylated by MK2 at serines 60 and 186.

Literature References

PubMed ID	Title	Journal	Year
18481987	Control of mRNA decay by phosphorylation of tristetraprolin Stoecklin, G, Sandler, H	Biochem Soc Trans	2008
14688255	MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding Shabanowitz, J, Sturgill, TW, Hunt, DF, Schroeder, MJ, Chrestensen, CA, Pelo, JW, Worthington, MT	J Biol Chem	2004
15014438	MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay Stubbs, T, Stoecklin, G, Blackwell, TK, Kedersha, N, Rigby, WF, Anderson, P, Wax, S	EMBO J	2004
15944294	Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function Bloch, DB, Collins, J, Roy, K, Brooks, SA, Rigby, S, Rigby, WF, Connolly, JE	J Immunol	2005
16262601	Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis Venable, JD, Kennington, EA, Yates, JR 3rd, Deterding, LJ, Tomer, KB, Blackshear, PJ, Cao, H	Biochem J	2006