MK2 phosphorylates ZFP36 (Tristetraproline, TTP)

Stable Identifier
Reaction [transition]
Homo sapiens
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TTP is phosphorylated by MK2 at serines 60 and 186.

Literature References
PubMed ID Title Journal Year
18481987 Control of mRNA decay by phosphorylation of tristetraprolin

Stoecklin, G, Sandler, H

Biochem Soc Trans 2008
14688255 MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

Shabanowitz, J, Sturgill, TW, Hunt, DF, Schroeder, MJ, Chrestensen, CA, Pelo, JW, Worthington, MT

J Biol Chem 2004
15014438 MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

Stubbs, T, Stoecklin, G, Blackwell, TK, Kedersha, N, Rigby, WF, Anderson, P, Wax, S

EMBO J 2004
15944294 Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function

Bloch, DB, Collins, J, Roy, K, Brooks, SA, Rigby, S, Rigby, WF, Connolly, JE

J Immunol 2005
16262601 Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis

Venable, JD, Kennington, EA, Yates, JR 3rd, Deterding, LJ, Tomer, KB, Blackshear, PJ, Cao, H

Biochem J 2006
Catalyst Activity

protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2 [cytosol]

Orthologous Events
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