ZFP36 (TTP) recruits RNA degradation activities

Stable Identifier
Reaction [binding]
Homo sapiens
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TTP interacts directly with exonucleases (XRN1 and the exosome) and decapping enzymes (DCP1a and DCP2) which hydrolyze the mRNA bound by TTP. TTP also recruits PARN deadenylase, however a direct interaction between TTP and PARN has not been demonstrated.

Literature References
PubMed ID Title Journal Year
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Karin, M, Stoecklin, G, Ong, SE, Gherzi, R, Mann, M, Chan, EL, Chen, CY, Raijmakers, R, Moroni, C, Pruijn, GJ

Cell 2001
12748283 Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease

Kennington, EA, Lai, WS, Blackshear, PJ

Mol Cell Biol 2003
17133347 Tristetraprolin recruits functional mRNA decay complexes to ARE sequences

Williams, DA, Walsh, RJ, Hau, HH, Ogilvie, RL, Bohjanen, PR, Reilly, CS

J Cell Biochem 2007
15687258 Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

Lykke-Andersen, J, Wagner, E

Genes Dev 2005
Orthologous Events
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