Reactome | IL18(1-36) [cytosol]

IL18(1-36) [cytosol]

Stable Identifier

R-HSA-449062

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IL18 N-term propeptide, Interleukin-18 N-terminal propeptide, IL18_HUMAN, IL18

Icon

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
        
        Interleukin-1 family N-terminal propeptides [cytosol] (Homo sapiens)
        
        IL18(1-36) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14116 IL18

Gene Names

IL18, IGIF, IL1F4

Chain

propeptide:1-36, chain:37-193

Reference Genes

COSMIC (genes):IL18 IL18

dbSNP Gene:3606 IL18

ENSEMBL:ENSG00000150782 IL18

Participates

as a member of

Interleukin-1 family N-terminal propeptides [cytosol] (Homo sapiens)

Other forms of this molecule

IL18 [extracellular region]

IL18 [cytosol]

IL18(1-193) [cytosol]

Inferred To

il1fma [cytosol] (Danio rerio)

Il18 [cytosol] (Mus musculus)

Il18 [cytosol] (Rattus norvegicus)

il1b [cytosol] (Xenopus tropicalis)

IL18 [cytosol] (Bos taurus)

IL18 [cytosol] (Canis familiaris)

IL18 [cytosol] (Sus scrofa)

Homologues of IL18(1-36) [cytosol] (Sus scrofa)

Homologues of IL18(1-36) [cytosol] (Xenopus tropicalis)

LOC105946938 [cytosol] (Xenopus tropicalis)

IL-18 [cytosol] (Gallus gallus)

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48594 SPB4			0.589	2
UniProt:Q9IW12 Q9IW12			0.558	2
UniProt:Q13478 IL18R1	1	IL18R1 [plasma membrane] (R-HSA-197600)	0.558	2
UniProt:Q15847 ADIRF	1	ADIRF [nucleoplasm] (R-HSA-8936822)	0.556	3
UniProt:Q9Y3C0 WASC3			0.527	2
UniProt:Q9BV97 ZNF747	1	ZNF747 [nucleoplasm] (R-HSA-2586596)	0.527	2
UniProt:P13385 TDGF1	1	N-aspartyl-glycosylphosphatidylinositolethanolamine-TDGF1(31-188) [plasma membrane] (R-HSA-452300)	0.527	2

Cite Us!