Reactome | IL18 [extracellular region]

IL18 [extracellular region]

Stable Identifier

R-HSA-448446

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

IL18(37-193), Interleukin-18

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        Interleukin-1 family are secreted (Homo sapiens)
        
        Interleukin-1 family [extracellular region] (Homo sapiens)
        
        IL18 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14116 IL18

Gene Names

IL18, IGIF, IL1F4

Chain

propeptide:1-36, chain:37-193

Reference Genes

BioGPS Gene:3606 IL18

COSMIC (genes):IL18 IL18

CTD Gene:3606 IL18

dbSNP Gene:3606 IL18

ENSEMBL:ENSG00000150782 IL18

HGNC:5986 IL18

KEGG:hsa:3606 IL18

Monarch:3606 IL18

NCBI Gene:3606 IL18

OMIM:600953 IL18

UCSC:Q14116 IL18

Reference Transcript

Participates

as a member of

as a component of

as an input of

Other forms of this molecule

IL18(1-193) [cytosol]

IL18 [cytosol]

IL18(1-36) [cytosol]

Inferred To

IL18 [extracellular region] (Bos taurus)

IL18 [extracellular region] (Canis familiaris)

IL18 [extracellular region] (Sus scrofa)

il1fma [extracellular region] (Danio rerio)

Homologues of IL18 [extracellular region] (Sus scrofa)

Homologues of IL18 [extracellular region] (Xenopus tropicalis)

Il18 [extracellular region] (Mus musculus)

Il18 [extracellular region] (Rattus norvegicus)

LOC105946938 [extracellular region] (Xenopus tropicalis)

il1b [extracellular region] (Xenopus tropicalis)

IL-18 [extracellular region] (Gallus gallus)

Cross References

OpenTargets

ENSG00000150782

ENSEMBL

ENSP00000434561, ENSP00000434161, ENST00000280357, ENSP00000280357, ENSG00000150782, ENST00000528832, ENST00000524595

HPA

ENSG00000150782-IL18

GeneCards

IL18

PRO

Q14116

Pharos - Targets

Q14116

GlyGen

Q14116

PDB

2VXT, 1J0S, 8J6K, 8SV1, 4EKX, 4R6U, 8SPB, 3F62, 3WO4, 4HJJ, 4XFU, 3WO3, 4XFT, 7AL7, 4XFS, 4EEE, 3WO2, 8URV

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48594 SPB4			0.589	2
UniProt:Q13478 IL18R1	1	IL18R1 [plasma membrane] (R-HSA-197600)	0.558	2
UniProt:Q9IW12 Q9IW12			0.558	2
UniProt:Q15847 ADIRF	1	ADIRF [nucleoplasm] (R-HSA-8936822)	0.556	3
UniProt:P13385 TDGF1	1	N-aspartyl-glycosylphosphatidylinositolethanolamine-TDGF1(31-188) [plasma membrane] (R-HSA-452300)	0.527	2
UniProt:Q9BV97 ZNF747	1	ZNF747 [nucleoplasm] (R-HSA-2586596)	0.527	2
UniProt:Q9Y3C0 WASC3			0.527	2

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