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IL18(37-193) [cytosol]
Stable Identifier
R-HSA-449023
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
IL18, Interleukin-18
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL18(37-193) [cytosol] (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL18(37-193) [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL18(37-193) [cytosol] (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL18(37-193) [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Non-canonical inflammasome activation (Homo sapiens)
CASP4-mediated substrate cleavage (Homo sapiens)
CASP4 cleaves IL18 at D36 (Homo sapiens)
IL18(37-193) [cytosol] (Homo sapiens)
CASP5-mediated substrate cleavage (Homo sapiens)
CASP5 cleaves IL18 at D36 (Homo sapiens)
IL18(37-193) [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
Interleukin-1 family [cytosol] (Homo sapiens)
IL18(37-193) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14116 IL18
Gene Names
IL18, IGIF, IL1F4
Chain
propeptide:1-36, chain:37-193
Reference Genes
COSMIC - genes:IL18 IL18
ENSEMBL:ENSG00000150782 IL18
HGNC:5986 IL18
UCSC:Q14116 IL18
Participates
as an output of
CASP4 cleaves IL18 at D36 (Homo sapiens)
CASP5 cleaves IL18 at D36 (Homo sapiens)
as a member of
Interleukin-1 family [cytosol] (Homo sapiens)
Other forms of this molecule
IL18 [extracellular region]
IL18(1-36) [cytosol]
IL18(1-193) [cytosol]
Inferred To
il1fma [cytosol]
(Danio rerio)
Homologues of IL18(37-193) [cytosol]
(Sus scrofa)
Homologues of IL18(37-193) [cytosol]
(Xenopus tropicalis)
Il18 [cytosol]
(Mus musculus)
Il18 [cytosol]
(Rattus norvegicus)
il1b [cytosol]
(Xenopus tropicalis)
IL18 [cytosol]
(Bos taurus)
IL18 [cytosol]
(Canis familiaris)
IL18 [cytosol]
(Sus scrofa)
LOC105946938 [cytosol]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000524595
,
ENST00000280357
,
ENSP00000434561
,
ENST00000528832
,
ENSP00000280357
,
ENSP00000434161
,
ENSG00000150782
OpenTargets
ENSG00000150782
HPA
ENSG00000150782-IL18
PRO
Q14116
Pharos - Targets
Q14116
GlyGen
Q14116
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48594 SPB4
0.589
2
UniProt:Q9IW12 Q9IW12
0.558
2
UniProt:Q13478 IL18R1
1
IL18R1 [plasma membrane]
(R-HSA-197600)
0.558
2
UniProt:Q15847 ADIRF
1
ADIRF [nucleoplasm]
(R-HSA-8936822)
0.556
3
UniProt:Q9Y3C0 WASC3
0.527
2
UniProt:Q9BV97 ZNF747
1
ZNF747 [nucleoplasm]
(R-HSA-2586596)
0.527
2
UniProt:P13385 CRIPTO
1
N-aspartyl-glycosylphosphatidylinositolethanolamine-TDGF1(31-188) [plasma membrane]
(R-HSA-452300)
0.527
2
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