PAN2-PAN3 complex partially deadenylates mRNA

Stable Identifier
Reaction [transition]
Homo sapiens
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The PAN2-PAN3 exoribonuclease complex hydrolyzes the poly(A) tail of a mRNA, shortening the tail from about 200 adenosine residues to about 80 adenosine residues and yielding adenosine 5'-monophosphate. PAN2 is the exoribonuclease component of the complex; PAN3 is required for cellular localization. The poly(A)-binding protein (PABP) interacts with PAN3 and recruits the PAN2-PAN3 complex to mRNA.
Literature References
PubMed ID Title Journal Year
14749774 The enzymes and control of eukaryotic mRNA turnover

Song, H, Parker, R

Nat Struct Mol Biol 2004
18625844 Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

Zhu, W, Ezzeddine, N, He, X, Zheng, D, Chen, CY, Shyu, AB

J Cell Biol 2008
16141059 From birth to death: the complex lives of eukaryotic mRNAs

Moore, MJ

Science 2005
14583602 Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein

Katada, T, Hoshino, S, Uchida, N

J Biol Chem 2004
15475613 Messenger RNA decay in mammalian cells: the exonuclease perspective

Fritz, DT, Wilusz, J, Bergman, N, Wilusz, CJ, Kilpatrick, WJ

Cell Biochem Biophys 2004
16284618 Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

Zhu, W, Chang, TC, Yamashita, A, Zhong, Z, Yamashita, Y, Chen, CY, Shyu, AB

Nat Struct Mol Biol 2005
19239894 The many pathways of RNA degradation

Houseley, J, Tollervey, D

Cell 2009
17245413 The highways and byways of mRNA decay

Garneau, NL, Wilusz, J, Wilusz, CJ

Nat Rev Mol Cell Biol 2007
11283721 The cap-to-tail guide to mRNA turnover

Wormington, M, Wilusz, CJ, Peltz, SW

Nat Rev Mol Cell Biol 2001
17595167 Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein

Siddiqui, N, Chang, TC, Palermino, JM, Mangus, DA, Gehring, K, Shyu, AB

J Biol Chem 2007
Catalyst Activity

poly(A)-specific ribonuclease activity of PAN2-PAN3 Complex [cytosol]

Orthologous Events
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