Reactome | PAN2-PAN3 complex partially deadenylates mRNA

PAN2-PAN3 complex partially deadenylates mRNA

Stable Identifier

R-HSA-430021

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PAN2-PAN3 complex partially deadenylates mRNA

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The PAN2-PAN3 exoribonuclease complex hydrolyzes the poly(A) tail of a mRNA, shortening the tail from about 200 adenosine residues to about 80 adenosine residues and yielding adenosine 5'-monophosphate. PAN2 is the exoribonuclease component of the complex; PAN3 is required for cellular localization. The poly(A)-binding protein (PABP) interacts with PAN3 and recruits the PAN2-PAN3 complex to mRNA.

Literature References

PubMed ID	Title	Journal	Year
14749774	The enzymes and control of eukaryotic mRNA turnover Parker, R, Song, H	Nat Struct Mol Biol	2004
18625844	Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells Zheng, D, Ezzeddine, N, Chen, CY, Zhu, W, He, X, Shyu, AB	J Cell Biol	2008
16141059	From birth to death: the complex lives of eukaryotic mRNAs Moore, MJ	Science	2005
14583602	Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein Uchida, N, Hoshino, S, Katada, T	J Biol Chem	2004
15475613	Messenger RNA decay in mammalian cells: the exonuclease perspective Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J	Cell Biochem Biophys	2004
16284618	Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover Yamashita, A, Chang, TC, Yamashita, Y, Zhu, W, Zhong, Z, Chen, CY, Shyu, AB	Nat Struct Mol Biol	2005
19239894	The many pathways of RNA degradation Houseley, J, Tollervey, D	Cell	2009
17245413	The highways and byways of mRNA decay Garneau, NL, Wilusz, J, Wilusz, CJ	Nat Rev Mol Cell Biol	2007
11283721	The cap-to-tail guide to mRNA turnover Wilusz, CJ, Wormington, M, Peltz, SW	Nat Rev Mol Cell Biol	2001
17595167	Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein Siddiqui, N, Mangus, DA, Chang, TC, Palermino, JM, Shyu, AB, Gehring, K	J Biol Chem	2007