Exosome Complex [cytosol]

Stable Identifier
R-HSA-429971
Type
Complex
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General

The exosome complex comprises a ring and associated subunits. The ring contains EXOSC2, EXOSC7, EXOSC8, EXOSC9, EXOSC5, and EXOSC6. The subunits EXOSC1, EXOSC2, EXOSC3, and RRP44 bind the ring. The catalytic ribonuclease site is located in RRP44, which yields ribonucleotides having 5'-monophosphates.

Literature References
PubMed ID Title Journal Year
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Chen, CY, Gherzi, R, Ong, SE, Chan, EL, Raijmakers, R, Pruijn, GJ, Stoecklin, G, Moroni, C, Mann, M, Karin, M

Cell 2001
Participants
Participant Of
Inferred To
Cross References
ComplexPortal