The exosome complex comprises a ring and associated subunits. The ring contains EXOSC2, EXOSC7, EXOSC8, EXOSC9, EXOSC5, and EXOSC6. The subunits EXOSC1, EXOSC2, EXOSC3, and RRP44 bind the ring. The catalytic ribonuclease site is located in RRP44, which yields ribonucleotides having 5'-monophosphates.
Karin, M, Stoecklin, G, Ong, SE, Gherzi, R, Mann, M, Chan, EL, Chen, CY, Raijmakers, R, Moroni, C, Pruijn, GJ
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