Exosome Complex [cytosol]

Stable Identifier
R-HSA-429971
Type
Complex
Species
Homo sapiens
Compartment
cytosol
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General
The exosome complex comprises a ring and associated subunits. The ring contains EXOSC2, EXOSC7, EXOSC8, EXOSC9, EXOSC5, and EXOSC6. The subunits EXOSC1, EXOSC2, EXOSC3, and RRP44 bind the ring. The catalytic ribonuclease site is located in RRP44, which yields ribonucleotides having 5'-monophosphates.
Literature References
PubMed ID Title Journal Year
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Karin, M, Stoecklin, G, Ong, SE, Gherzi, R, Mann, M, Chan, EL, Chen, CY, Raijmakers, R, Moroni, C, Pruijn, GJ

Cell 2001
Participants
components
Participates
as an input of
as a component of
Inferred To
Exosome Complex [cytosol] (Bos taurus)
Exosome Complex [cytosol] (Caenorhabditis elegans)
Exosome Complex [cytosol] (Canis familiaris)
Exosome Complex [cytosol] (Dictyostelium discoideum)
Exosome Complex [cytosol] (Drosophila melanogaster)
Exosome Complex [cytosol] (Gallus gallus)
Exosome Complex [cytosol] (Mus musculus)
Exosome Complex [cytosol] (Rattus norvegicus)
Exosome Complex [cytosol] (Saccharomyces cerevisiae)
Exosome Complex [cytosol] (Schizosaccharomyces pombe)
Exosome Complex [cytosol] (Sus scrofa)
Exosome Complex [cytosol] (Xenopus tropicalis)
Cross References
ComplexPortal
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