BRF1 Complex recruits RNA degradation activities

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BRF1 recruits RNA degradation activities to hydrolyze the RNA bound to BRF1. Coimmunoprecipitation has shown BRF1 interacts with the exosome (3' to 5' nuclease), XRN1 (5' to 3' nuclease), and DCP1a and DCP2 (decapping). BRF1 localizes RNAs to processing bodies, sites of translation repression and possible sites of RNA degradation.

Literature References
PubMed ID Title Journal Year
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Karin, M, Stoecklin, G, Ong, SE, Gherzi, R, Mann, M, Chan, EL, Chen, CY, Raijmakers, R, Moroni, C, Pruijn, GJ

Cell 2001
15687258 Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

Lykke-Andersen, J, Wagner, E

Genes Dev 2005
14976220 Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference

Certa, U, Gross, B, Wegmueller, D, Raineri, I, Moroni, C

Nucleic Acids Res 2004
17369404 TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements

Franks, TM, Lykke-Andersen, J

Genes Dev 2007
Orthologous Events
Cite Us!