KSRP recruits RNA degradation activities

Stable Identifier
Reaction [binding]
Homo sapiens
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KSRP (KHSRP) forms a complex with the PARN deadenylase, exosome components (3' to 5' mRNA decay), and the decapping enzyme DCP2. Tethering KSRP to a mRNA is sufficient to target the mRNA for degradation.

Literature References
PubMed ID Title Journal Year
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Karin, M, Stoecklin, G, Ong, SE, Gherzi, R, Mann, M, Chan, EL, Chen, CY, Raijmakers, R, Moroni, C, Pruijn, GJ

Cell 2001
15175153 A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery

Karin, M, Briata, P, Wegmüller, D, Gherzi, R, Chen, CY, Moroni, C, Lee, KY

Mol Cell 2004
16648466 Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay

Chou, CF, Lin, WJ, Maitra, S, Gherzi, R, Chen, CY, Kappes, J, Mulky, A

Mol Cell Biol 2006
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