KSRP recruits RNA degradation activities

Stable Identifier
R-HSA-450422
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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KSRP recruits RNA degradation activities
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KSRP (KHSRP) forms a complex with the PARN deadenylase, exosome components (3' to 5' mRNA decay), and the decapping enzyme DCP2. Tethering KSRP to a mRNA is sufficient to target the mRNA for degradation.
Literature References
PubMed ID Title Journal Year
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Chen, CY, Gherzi, R, Ong, SE, Chan, EL, Raijmakers, R, Pruijn, GJ, Stoecklin, G, Moroni, C, Mann, M, Karin, M

Cell 2001
15175153 A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery

Gherzi, R, Lee, KY, Briata, P, Wegmüller, D, Moroni, C, Karin, M, Chen, CY

Mol Cell 2004
16648466 Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay

Chou, CF, Mulky, A, Maitra, S, Lin, WJ, Gherzi, R, Kappes, J, Chen, CY

Mol Cell Biol 2006
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Orthologous Events
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Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-17)
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