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GCG(21-180) [secretory granule lumen]
Stable Identifier
R-HSA-421418
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
Proglucagon, Glucagon precursor (Contains: Glicentin; Glicentin-related polypeptide), GCG
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)
GCG(21-180) [secretory granule lumen] (Homo sapiens)
Proglucagon translocates from the ER Lumen to secretory granules (Homo sapiens)
GCG(21-180) [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01275 GCG
Gene Names
GCG
Chain
signal peptide:1-20, peptide:21-89, peptide:21-50, peptide:53-89, peptide:53-81, propeptide:84-89, peptide:92-128, peptide:98-128, peptide:98-127, propeptide:131-145, peptide:146-178
Reference Genes
BioGPS Gene:2641 GCG
COSMIC (genes):GCG GCG
CTD Gene:2641 GCG
dbSNP Gene:2641 GCG
ENSEMBL:ENSG00000115263.15 GCG
ENSEMBL_Homo_sapiens_GENE GCG
HGNC:4191 GCG
KEGG Gene (Homo sapiens):2641 GCG
Monarch:2641 GCG
NCBI Gene:2641 GCG
OMIM:138030 GCG
UCSC:P01275 GCG
Reference Transcript
RefSeq:NM_002054.4 GCG
Other Identifiers
11742762_at
16904315
206422_PM_at
206422_at
2584112
2584114
2584115
2584116
2584117
2584120
2584121
2584123
2584124
2584126
2584127
2641
39726_at
8056250
A_23_P254664
A_33_P3298460
A_33_P3369336
GE85596
GO:0005102
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005783
GO:0005788
GO:0005886
GO:0005975
GO:0006094
GO:0007186
GO:0007188
GO:0007189
GO:0007631
GO:0010737
GO:0010800
GO:0012501
GO:0014823
GO:0023052
GO:0031410
GO:0031769
GO:0032092
GO:0033138
GO:0034774
GO:0035774
GO:0036211
GO:0042593
GO:0042802
GO:0043066
GO:0043226
GO:0045722
GO:0045860
GO:0048018
GO:0050796
GO:0051571
GO:0070374
GO:0071377
GO:0090280
GO:0098772
GO:1900118
HMNXSV003012132
ILMN_1724396
J04040_at
PH_hs_0019793
TC02002479.hg
g4503944_3p_at
g4503944_3p_x_at
Participates
as an output of
Proglucagon translocates from the ER Lumen to secretory granules (Homo sapiens)
as an input of
PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)
Other forms of this molecule
GCG(100-128) [extracellular region]
ArgN-GCG(100-127) [extracellular region]
GCG(1-180) [endoplasmic reticulum lumen]
GCG(21-180) [endoplasmic reticulum lumen]
ArgN-GCG(98-127) [secretory granule lumen]
GLP-1 (7-37) [secretory granule lumen]
GCG(146-178) [extracellular region]
ArgN-GCG(98-127) [extracellular region]
GLP-1 (7-37) [extracellular region]
GCG(53-81) [extracellular region]
Inferred To
GCG(21-180) [secretory granule lumen]
(Canis familiaris)
GCG(21-180) [secretory granule lumen]
(Danio rerio)
Proglucagon [secretory granule lumen]
(Mus musculus)
gcg [secretory granule lumen]
(Xenopus tropicalis)
GCG [secretory granule lumen]
(Bos taurus)
GCG [secretory granule lumen]
(Gallus gallus)
GCG [secretory granule lumen]
(Sus scrofa)
Gcg [secretory granule lumen]
(Rattus norvegicus)
Cross References
RefSeq
NP_002045.1
OpenTargets
ENSG00000115263
GeneCards
P01275
HPA
ENSG00000115263-GCG
ZINC - Substances
GLUC_HUMAN
ZINC target
P01275
Ensembl
ENSP00000364647
,
ENST00000375497
,
ENSG00000115263
,
ENST00000418842
,
ENSP00000387662
PRO
P01275
Pharos - Targets
P01275
ZINC - Predictions - Purchasable
GLUC_HUMAN
HMDB Protein
HMDBP13585
PDB
6LMK
,
7D68
,
6VCB
,
6PHI
,
2L64
,
6PHJ
,
1NAU
,
2L63
,
6PHL
,
2M5Q
,
3IOL
,
5OTU
,
6LML
,
4APD
,
6PHK
,
2M5P
,
6EDS
,
5VAI
,
7DUQ
,
6PHP
,
5OTW
,
7KI0
,
7KI1
,
6PHO
,
4ZGM
,
1D0R
,
6X18
,
5OTV
,
1BH0
,
2G49
,
5OTX
,
5YQZ
,
6NZN
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14735-1 IDE
0.618
3
UniProt:P01275 GCG
11
GCG(100-128) [extracellular region]
(R-HSA-400472)
ArgN-GCG(100-127) [extracellular region]
(R-HSA-400534)
GCG(1-180) [endoplasmic reticulum lumen]
(R-HSA-400456)
GCG(21-180) [endoplasmic reticulum lumen]
(R-HSA-381774)
GCG(21-180) [secretory granule lumen]
(R-HSA-421418)
ArgN-GCG(98-127) [secretory granule lumen]
(R-HSA-421419)
GLP-1 (7-37) [secretory granule lumen]
(R-HSA-421422)
GCG(146-178) [extracellular region]
(R-HSA-420211)
ArgN-GCG(98-127) [extracellular region]
(R-HSA-381699)
GLP-1 (7-37) [extracellular region]
(R-HSA-381636)
GCG(53-81) [extracellular region]
(R-HSA-163626)
0.598
3
UniProt:P48546 GIPR
1
GIPR [plasma membrane]
(R-HSA-420132)
0.558
2
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