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Proglucagon translocates from the ER Lumen to secretory granules
Stable Identifier
R-HSA-421416
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
,
secretory granule lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
Proglucagon translocates from the ER Lumen to secretory granules (Homo sapiens)
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Proglucagon transits from the lumen of the endoplasmic reticulum to secretory granules.
Literature References
PubMed ID
Title
Journal
Year
3900195
Localization of glucagon-like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry
Uttenthal, LO
,
Sikri, KL
,
Varndell, IM
,
Bishop, AE
,
Polak, JM
,
Bloom, SR
J Histochem Cytochem
1985
Participants
Input
GCG(21-180) [endoplasmic reticulum lumen]
(Homo sapiens)
Output
GCG(21-180) [secretory granule lumen]
(Homo sapiens)
Participates
as an event of
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
Orthologous Events
Proglucagon translocates from the ER Lumen to secretory granules (Bos taurus)
Proglucagon translocates from the ER Lumen to secretory granules (Canis familiaris)
Proglucagon translocates from the ER Lumen to secretory granules (Gallus gallus)
Proglucagon translocates from the ER Lumen to secretory granules (Mus musculus)
Proglucagon translocates from the ER Lumen to secretory granules (Rattus norvegicus)
Proglucagon translocates from the ER Lumen to secretory granules (Sus scrofa)
Proglucagon translocates from the ER Lumen to secretory granules (Xenopus tropicalis)
Authored
May, B (2009-05-19)
Reviewed
Bloom, SR (2010-06-25)
Created
May, B (2009-05-19)
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