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GLP-1 (7-37) [secretory granule lumen]
Stable Identifier
R-HSA-421422
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
GCG(98-128), Glucagon-like Peptide-1 (7-37)
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)
mature GLP-1 [secretory granule lumen] (Homo sapiens)
GLP-1 (7-37) [secretory granule lumen] (Homo sapiens)
PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)
mature GLP-1 [secretory granule lumen] (Homo sapiens)
GLP-1 (7-37) [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01275 GCG
Gene Names
GCG
Chain
signal peptide:1-20, peptide:21-89, peptide:21-50, peptide:53-89, peptide:53-81, propeptide:84-89, peptide:92-128, peptide:98-128, peptide:98-127, propeptide:131-145, peptide:146-178
Reference Genes
BioGPS Gene:2641 GCG
COSMIC (genes):GCG GCG
CTD Gene:2641 GCG
dbSNP Gene:2641 GCG
ENSEMBL_Homo_sapiens_GENE GCG
HGNC:4191 GCG
KEGG Gene (Homo sapiens):2641 GCG
Monarch:2641 GCG
NCBI Gene:2641 GCG
OMIM:138030 GCG
UCSC:P01275 GCG
Reference Transcript
RefSeq:NM_002054.4 GCG
Other Identifiers
0002570139
11742762_at
16904315
206422_at
2584112
2584114
2584115
2584116
2584117
2584120
2584121
2584123
2584124
2584126
2584127
2641
39726_at
8056250
A_23_P254664
A_33_P3298460
A_33_P3369336
GE85596
GO:0002376
GO:0002862
GO:0003674
GO:0005102
GO:0005179
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005975
GO:0006464
GO:0006810
GO:0006950
GO:0007165
GO:0007186
GO:0007188
GO:0007189
GO:0007267
GO:0007631
GO:0008150
GO:0008219
GO:0009058
GO:0010737
GO:0010800
GO:0014823
GO:0015031
GO:0031410
GO:0031769
GO:0032092
GO:0033138
GO:0034774
GO:0035774
GO:0042592
GO:0042593
GO:0042802
GO:0043066
GO:0043226
GO:0044281
GO:0045722
GO:0045860
GO:0050796
GO:0051276
GO:0051571
GO:0070374
GO:0071377
GO:0090280
GO:1900118
HMNXSV003012132
ILMN_1724396
J04040_at
PH_hs_0019793
TC02002479.hg
g4503944_3p_at
g4503944_3p_x_at
Participates
as a member of
mature GLP-1 [secretory granule lumen] (Homo sapiens)
Other forms of this molecule
GCG(100-128) [extracellular region]
ArgN-GCG(100-127) [extracellular region]
GCG(1-180) [endoplasmic reticulum lumen]
GCG(21-180) [endoplasmic reticulum lumen]
GCG(21-180) [secretory granule lumen]
ArgN-GCG(98-127) [secretory granule lumen]
GCG(146-178) [extracellular region]
ArgN-GCG(98-127) [extracellular region]
GLP-1 (7-37) [extracellular region]
GCG(53-81) [extracellular region]
Inferred To
gcg [secretory granule lumen]
(Xenopus tropicalis)
GCG [secretory granule lumen]
(Bos taurus)
GCG [secretory granule lumen]
(Canis familiaris)
GCG [secretory granule lumen]
(Gallus gallus)
Glucagon-like Peptide-1 (7-37) [secretory granule lumen]
(Mus musculus)
Gcg [secretory granule lumen]
(Rattus norvegicus)
gcgb [secretory granule lumen]
(Danio rerio)
Cross References
RefSeq
NP_002045.1
OpenTargets
ENSG00000115263
HPA
ENSG00000115263-GCG
GeneCards
P01275
ZINC - Substances
GLUC_HUMAN
ZINC target
P01275
Ensembl
ENST00000418842
,
ENSP00000387662
,
ENSP00000364647
,
ENSG00000115263
,
ENST00000375497
PRO
P01275
Pharos - Targets
P01275
ZINC - Predictions - Purchasable
GLUC_HUMAN
HMDB Protein
HMDBP13585
PDB
1NAU
,
7D68
,
6PHP
,
6LML
,
2M5P
,
2L64
,
2L63
,
6PHL
,
5OTX
,
6LMK
,
6PHO
,
3IOL
,
4ZGM
,
2M5Q
,
1BH0
,
5OTU
,
6PHJ
,
1D0R
,
6PHK
,
5OTV
,
7DUQ
,
5OTW
,
2G49
,
5VAI
,
6PHI
,
4APD
,
6X18
,
5YQZ
,
6VCB
,
6EDS
,
6NZN
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14735-1 IDE
0.618
3
UniProt:P01275 GCG
11
GCG(100-128) [extracellular region]
(R-HSA-400472)
ArgN-GCG(100-127) [extracellular region]
(R-HSA-400534)
GCG(1-180) [endoplasmic reticulum lumen]
(R-HSA-400456)
GCG(21-180) [endoplasmic reticulum lumen]
(R-HSA-381774)
GCG(21-180) [secretory granule lumen]
(R-HSA-421418)
ArgN-GCG(98-127) [secretory granule lumen]
(R-HSA-421419)
GLP-1 (7-37) [secretory granule lumen]
(R-HSA-421422)
GCG(146-178) [extracellular region]
(R-HSA-420211)
ArgN-GCG(98-127) [extracellular region]
(R-HSA-381699)
GLP-1 (7-37) [extracellular region]
(R-HSA-381636)
GCG(53-81) [extracellular region]
(R-HSA-163626)
0.598
3
UniProt:P48546 GIPR
1
GIPR [plasma membrane]
(R-HSA-420132)
0.558
2
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