Reactome | ArgN-GCG(98-127) [extracellular region]

ArgN-GCG(98-127) [extracellular region]

Stable Identifier

R-HSA-381699

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

GLP-1 (7-36) amide, Glucagon-like Peptide-1 (7-36) amide

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General

The amide group at the C-terminus is not necessary for biological activity.

External Reference Information

External Reference

UniProt:P01275 GCG

Gene Names

GCG

Chain

signal peptide:1-20, peptide:21-89, peptide:21-50, peptide:53-89, peptide:53-81, propeptide:84-89, peptide:92-128, peptide:98-128, peptide:98-127, propeptide:131-145, peptide:146-178

Reference Genes

BioGPS Gene:2641 GCG

COSMIC (genes):GCG GCG

CTD Gene:2641 GCG

dbSNP Gene:2641 GCG

ENSEMBL:ENSG00000115263 GCG

ENSEMBL_homo_sapiens_GENE:ENSG00000115263.15 GCG

HGNC:4191 GCG

KEGG Gene (Homo sapiens):2641 GCG

Monarch:2641 GCG

NCBI Gene:2641 GCG

OMIM:138030 GCG

UCSC:P01275 GCG

Reference Transcript

RefSeq:NM_002054.4 GCG

Other Identifiers

11742762_at

16904315

206422_PM_at

206422_at

2584112

2584114

2584115

2584116

2584117

2584120

2584121

2584123

2584124

2584126

2584127

2641

39726_at

8056250

A_23_P254664

A_33_P3298460

A_33_P3369336

GE85596

GO:0005102

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005783

GO:0005788

GO:0005886

GO:0005975

GO:0006094

GO:0007186

GO:0007188

GO:0007189

GO:0007631

GO:0010737

GO:0010800

GO:0012501

GO:0014823

GO:0023052

GO:0031410

GO:0031769

GO:0033138

GO:0034774

GO:0035774

GO:0036211

GO:0042593

GO:0042802

GO:0043066

GO:0043226

GO:0045722

GO:0048018

GO:0050796

GO:0050896

GO:0051571

GO:0070374

GO:0071377

GO:0090280

GO:0098772

GO:1900118

HMNXSV003012132

ILMN_1724396

J04040_at

PH_hs_0019793

TC02002479.hg

g4503944_3p_at

g4503944_3p_x_at

Participates

as a member of

mature GLP1 [extracellular region] (Homo sapiens)

Other forms of this molecule

GCG(100-128) [extracellular region]

ArgN-GCG(100-127) [extracellular region]

GCG(1-180) [endoplasmic reticulum lumen]

GCG(21-180) [endoplasmic reticulum lumen]

GCG(21-180) [secretory granule lumen]

ArgN-GCG(98-127) [secretory granule lumen]

GLP-1 (7-37) [secretory granule lumen]

GCG(146-178) [extracellular region]

GLP-1 (7-37) [extracellular region]

GCG(53-81) [extracellular region]

Inferred To

GCG [extracellular region] (Bos taurus)

GCG [extracellular region] (Canis familiaris)

GCG [extracellular region] (Gallus gallus)

GCG [extracellular region] (Sus scrofa)

Gcg [extracellular region] (Mus musculus)

Gcg [extracellular region] (Rattus norvegicus)

gcg [extracellular region] (Xenopus tropicalis)

Modified Residues

Name

L-arginine amide at 127

Coordinate

127

PsiMod Name

L-arginine amide [MOD:00091]

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to L-arginine amide.

Cross References

RefSeq

NP_002045.1

OpenTargets

ENSG00000115263

GeneCards

P01275

ZINC - Substances

GLUC_HUMAN

HPA

ENSG00000115263-GCG

ZINC target

P01275

Ensembl

ENST00000375497, ENSG00000115263, ENSP00000364647, ENST00000418842, ENSP00000387662

PRO

P01275

Pharos - Targets

P01275

ZINC - Predictions - Purchasable

GLUC_HUMAN

HMDB Protein

HMDBP13585

PDB

6PHI, 6LMK, 7XM8, 8ANJ, 8ANK, 1NAU, 6VCB, 6PHJ, 6LML, 7D68, 6PHK, 2G49, 2L63, 6X18, 4APD, 6PHL, 2L64, 8JRV, 5OTU, 7KI0, 6PHO, 1BH0, 2M5P, 3IOL, 6EDS, 2M5Q, 1D0R, 5VAI, 5OTV, 5OTW, 7KI1, 4ZGM, 7DUQ, 6PHP, 6NZN, 5YQZ, 5OTX

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14735-1 IDE			0.618	3
UniProt:P01275 GCG	11	GCG(100-128) [extracellular region] (R-HSA-400472) ArgN-GCG(100-127) [extracellular region] (R-HSA-400534) GCG(1-180) [endoplasmic reticulum lumen] (R-HSA-400456) GCG(21-180) [endoplasmic reticulum lumen] (R-HSA-381774) GCG(21-180) [secretory granule lumen] (R-HSA-421418) ArgN-GCG(98-127) [secretory granule lumen] (R-HSA-421419) GLP-1 (7-37) [secretory granule lumen] (R-HSA-421422) GCG(146-178) [extracellular region] (R-HSA-420211) ArgN-GCG(98-127) [extracellular region] (R-HSA-381699) GLP-1 (7-37) [extracellular region] (R-HSA-381636) GCG(53-81) [extracellular region] (R-HSA-163626)	0.598	3
UniProt:P48546 GIPR	1	GIPR [plasma membrane] (R-HSA-420132)	0.558	2