Reactome | monoSUMO1-K499,K538-MBD1 [nucleoplasm]

monoSUMO1-K499,K538-MBD1 [nucleoplasm]

Stable Identifier

R-HSA-4090331

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Methyl-CpG-binding domain protein 1, MBD1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UIS9 MBD1

Gene Names

MBD1, CXXC3, PCM1

Chain

chain:1-605

Reference Genes

BioGPS Gene:4152 MBD1

COSMIC (genes):MBD1 MBD1

COSMIC (genes):PCM1 MBD1

CTD Gene:4152 MBD1

dbSNP Gene:4152 MBD1

ENSEMBL:ENSG00000141644 MBD1

HGNC:6916 MBD1

KEGG:hsa:4152 MBD1

Monarch:4152 MBD1

NCBI Gene:4152 MBD1

OMIM:156535 MBD1

UCSC:Q9UIS9 MBD1

Reference Transcript

Other Identifiers

11748954_x_at

11749180_a_at

11755322_a_at

11755323_x_at

11759747_a_at

11761026_x_at

203353_PM_s_at

203353_s_at

226862_PM_at

226862_at

241813_3p_at

241813_PM_at

241813_at

3807750

3807751

3807752

3807754

3807755

3807756

3807757

3807758

3807759

3807760

3807761

3807762

3807763

3807764

3807765

3807766

3807767

3807770

3807771

3807773

3807775

3807777

3807778

3807780

3807783

3807784

3807786

3807790

3807791

3807794

3807797

3807799

3807804

3807805

3807807

3807808

4152

41828_at

57263_at

59373_at

87170_at

90441_at

A_23_P208090

A_24_P185347

A_24_P925124

A_33_P3398922

A_33_P3398927

A_33_P3398932

GE82036

GO:0000122

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006346

GO:0006351

GO:0006355

GO:0006366

GO:0008270

GO:0008327

GO:0010385

GO:0016363

GO:0016607

GO:0045322

GO:0045892

GO:0046872

HMNXSV003010400

HMNXSV003016036

HMNXSV003048735

Hs.214140.0.S1_3p_at

Hs.214140.0.S1_3p_x_at

Hs.6211.4.S1_3p_at

ILMN_1683595

ILMN_2352580

PH_hs_0024657

TC18000512.hg

g7710136_3p_a_at

g7710138_3p_a_at

Participates

as an output of

PIAS1,3 SUMOylate MBD1 with SUMO1 (Homo sapiens)

Other forms of this molecule

MBD1 [nucleoplasm]

Inferred To

Mbd1 [nucleoplasm] (Mus musculus)

Mbd1 [nucleoplasm] (Rattus norvegicus)

mbd-2 [nucleoplasm] (Caenorhabditis elegans)

MBD1 [nucleoplasm] (Sus scrofa)

mbd1b [nucleoplasm] (Danio rerio)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 499

Coordinate

499

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 538

Coordinate

538

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001191071.1, NP_001191072.1, NP_001191070.1, NP_001375069.1, NP_001386871.1, XP_005258328.1, NP_001386870.1, NP_002375.1, NP_056670.2, NP_056671.2, NP_001386815.1, XP_011524308.1, NP_001191069.1, NP_001191068.1, NP_001375073.1, XP_016881265.1, XP_054174613.1, XP_016881260.1, XP_011524295.1, NP_001191065.1, XP_016881249.1, NP_001191080.1, NP_001386827.1, NP_001386826.1, XP_011524296.1, NP_001191066.1, NP_001191067.1, XP_054174603.1, NP_001386886.1, NP_056669.2, XP_054174616.1, NP_056723.2, XP_016881259.1, NP_001375067.1

OpenTargets

ENSG00000141644

ENSEMBL

ENSP00000269469, ENSP00000468430, ENST00000269468, ENSP00000269468, ENST00000382948, ENST00000585672, ENST00000457839, ENST00000585595, ENST00000587605, ENST00000588937, ENST00000347968, ENSP00000467763, ENST00000398493, ENSP00000285102, ENSP00000466092, ENSP00000339546, ENSP00000468042, ENST00000398488, ENSP00000381506, ENSP00000465923, ENSP00000381502, ENSG00000141644, ENSP00000269471, ENST00000269471, ENST00000339998, ENST00000591535, ENST00000590208, ENST00000353909, ENST00000591416, ENSP00000468785, ENSP00000467017, ENSP00000372407, ENSP00000405268

GeneCards

MBD1

HPA

ENSG00000141644-MBD1

PRO

Q9UIS9

Pharos - Targets

Q9UIS9

GlyGen

Q9UIS9

HMDB Protein

HMDBP10775

PDB

5W9Q, 1D9N, 6D1T, 1IG4, 4D4W

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.702	6
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.581	3
UniProt:Q9Y6X2 PIAS3	1	PIAS3 [nucleoplasm] (R-HSA-2993764)	0.581	3
UniProt:Q13111 CAF1A			0.581	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.581	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.576	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.556	5
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.524	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.524	2
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.524	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.508	2
UniProt:Q99435 NELL2	1	NELL2 [extracellular region] (R-HSA-9010198)	0.508	2
UniProt:Q15156 Q15156			0.499	4

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