Reactome | SUV39H1 [nucleoplasm]

SUV39H1 [nucleoplasm]

Stable Identifier

R-HSA-427517

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

KMT1A, Histone-lysine N-methyltransferase SUV39H1, SUV91_HUMAN

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External Reference Information

External Reference

UniProt:O43463 SUV39H1

Gene Names

SUV39H1, KMT1A, SUV39H

Chain

chain:1-412

Reference Genes

BioGPS Gene:6839 SUV39H1

COSMIC (genes):SUV39H1 SUV39H1

CTD Gene:6839 SUV39H1

dbSNP Gene:6839 SUV39H1

ENSEMBL:ENSG00000101945 SUV39H1

HGNC:11479 SUV39H1

Monarch:6839 SUV39H1

NCBI Gene:6839 SUV39H1

OMIM:300254 SUV39H1

UCSC:O43463 SUV39H1

Reference Transcript

Other Identifiers

11721277_a_at

11721278_s_at

11721279_x_at

11746768_a_at

11752693_a_at

17103413

218619_PM_s_at

218619_s_at

3976798

3976801

3976802

3976804

3976805

3976807

3976808

3976809

3976810

45149_at

6839

8167347

A_14_P137016

A_23_P422193

A_33_P3407524

GE58298

GO:0000122

GO:0000183

GO:0000228

GO:0000775

GO:0000792

GO:0000794

GO:0000976

GO:0003677

GO:0003682

GO:0003824

GO:0005515

GO:0005634

GO:0005652

GO:0005654

GO:0005677

GO:0005694

GO:0005730

GO:0005886

GO:0006325

GO:0006355

GO:0006364

GO:0006974

GO:0007623

GO:0008168

GO:0008270

GO:0008757

GO:0016740

GO:0030154

GO:0031410

GO:0032259

GO:0033553

GO:0042054

GO:0042149

GO:0043226

GO:0044725

GO:0045786

GO:0045892

GO:0046015

GO:0046872

GO:0046974

GO:0048511

GO:0061773

GO:0071456

GO:0097009

GO:0140096

GO:0140938

GO:0140949

HMNXSV003055733

ILMN_1781479

PH_hs_0002968

TC0X000258.hg

g4507320_3p_s_at

Participates

as an input of

Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)

as a component of

eNoSC [nucleoplasm] (Homo sapiens)

as a member of

SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of SUV39H1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of SUV39H1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of SUV39H1 [nucleoplasm] (Schizosaccharomyces pombe)

SUV39H1 [nucleoplasm] (Bos taurus)

SUV39H1 [nucleoplasm] (Canis familiaris)

SUV39H1 [nucleoplasm] (Drosophila melanogaster)

SUV39H1 [nucleoplasm] (Mus musculus)

SUV39H1 [nucleoplasm] (Rattus norvegicus)

SUV39H1 [nucleoplasm] (Sus scrofa)

Cross References

ZINC - World Drugs

SUV91_HUMAN

Guide to Pharmacology - Targets

2715

OpenTargets

ENSG00000101945

ENSEMBL

ENSP00000365877, ENSP00000337976, ENST00000376687, ENST00000337852

ZINC - Substances

SUV91_HUMAN

ZINC - Biogenic

SUV91_HUMAN

ZINC target

O43463

PRO

O43463

PDB

3MTS

ZINC - Metabolites

SUV91_HUMAN

IntEnz

2.1.1.355

HPA

ENSG00000101945-SUV39H1

Pharos - Targets

O43463

ZINC - Predictions - Purchasable

SUV91_HUMAN

HMDB Protein

HMDBP00422

Interactors (65)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.949	18
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.8	9
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.742	6
UniProt:Q9BRK4 LZTS2			0.718	6
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.718	6
UniProt:Q96ED9 HOOK2			0.666	4
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:V9HWG0 V9HWG0			0.556	3
UniProt:Q8N680 ZBTB2			0.556	3
UniProt:Q8WW24 TEKT4			0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
IntAct:EBI-25911596 CCSB			0.556	3
UniProt:Q9UIS9 MBD1	2	MBD1 [nucleoplasm] (R-HSA-417134) monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331)	0.556	5
UniProt:Q6TGC4 PADI6	2	PADI6 [cytosol] (R-HSA-1183183) PADI6 [nucleoplasm] (R-HSA-6793449)	0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
UniProt:Q96I34 PP16A			0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:Q9C0K0 BC11B			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.544	5
UniProt:Q15018 FAM175B	1	FAM175B [cytosol] (R-HSA-5691428)	0.527	2
UniProt:O60732 MAGC1			0.527	2
UniProt:Q9UPU5 USP24	1	USP24 [nucleoplasm] (R-HSA-5697004)	0.527	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.527	2
UniProt:Q9NPA3 MID1IP1	1	MID1IP1 [cytosol] (R-HSA-8867328)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.524	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.524	3
UniProt:Q15156 Q15156			0.524	4
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.524	3
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.508	2
UniProt:O95260 ATE1			0.508	2
UniProt:Q9NS23 RASF1			0.508	2
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.508	2
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.508	2
UniProt:P49761 CLK3			0.508	2
UniProt:Q6ZNL6 FGD5	1	FGD5 [cytosol] (R-HSA-9714447)	0.508	2
UniProt:Q9C0F3 ZNF436	1	ZNF436 [nucleoplasm] (R-HSA-1247538)	0.508	2
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.508	2
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.508	2
UniProt:Q5TAQ9 DCAF8	1	DCAF8 [nucleoplasm] (R-HSA-8955192)	0.508	2
UniProt:Q9BXL8 CDCA4			0.508	2
UniProt:Q9BS31 ZNF649	1	ZNF649 [nucleoplasm] (R-HSA-2127585)	0.508	2
UniProt:Q9BS34 ZNF670	1	ZNF670 [nucleoplasm] (R-HSA-2248887)	0.508	2
UniProt:Q6P047 CH074			0.508	2
UniProt:Q8N4C7 STX19			0.508	2
UniProt:Q9NWQ4 GPT2L			0.508	2
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.508	2
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.508	2
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.508	2
UniProt:Q9Y2L8 ZKSCAN5	1	ZKSCAN5 [nucleoplasm] (R-HSA-975021)	0.508	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.508	2
UniProt:P50749 RASF2			0.508	2
UniProt:Q8TBB5 KLDC4			0.508	2
UniProt:A5D8V7 ODAD3			0.508	2
UniProt:Q9H9B1-1 EHMT1			0.462	2
UniProt:Q96KQ7-1 EHMT2			0.462	2