Signal peptidase hydrolyzes preproGIP to proGIP

Stable Identifier
R-HSA-400496
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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Signal peptidase hydrolyzes preproGIP to proGIP
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The GIP mRNA is translated by ribosomes at the outer surface of the rough endoplasmic reticulum. The nascent peptide enters the endoplasmic reticulum through the translocon complex and the signal peptide is cleaved by the signal peptidase.
Literature References
PubMed ID Title Journal Year
2890159 Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor

Tobe, T, Tanaka, K, Kurono, M, Takeda, J, Suzuki, T, Takahashi, H, Kayano, T, Mitani, T, Fukumoto, H, Seino, Y

Proc Natl Acad Sci U S A 1987
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as an event of
Catalyst Activity

serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]

Physical Entity
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Signal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin (Bos taurus)
Authored
May, B  (2009-05-19)
Reviewed
Bloom, SR  (2010-06-25)
Created
May, B  (2009-03-24)
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