Signal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin

Stable Identifier
R-NUL-445309
Type
Reaction [transition]
Species
Bos taurus
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
High
 | PPTX  | SBGN
Signal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin
The signal peptide is cleaved by the signal peptidase complex, which contains 5 subunits. Based on homology with bacterial signal peptidases the SEC11A and SEC11C subunits are believed to be the actual proteases. The reaction shown here was demonstrated in vitro.
Literature References
PubMed ID Title Journal Year
3511473 Purification of microsomal signal peptidase as a complex

Evans, EA, Blobel, G, Gilmore, R

Proc Natl Acad Sci U S A 1986
Participants
Input
Output
Catalyst Activity

serine-type endopeptidase activity of Signal Peptidase Complex (Canis familiaris) [endoplasmic reticulum membrane]

Physical Entity
Signal Peptidase Complex (Canis familiaris) [endoplasmic reticulum membrane] (Canis familiaris)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 (Homo sapiens)
Signal peptidase hydrolyzes preproGIP to proGIP (Homo sapiens)
Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)
Authored
May, B  (2009-10-29)
Reviewed
May, B  (2009-10-29)
Created
May, B  (2009-10-29)
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