Prostacyclin signalling through prostacyclin receptor

Stable Identifier
R-HSA-392851
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Prostacyclin signalling through prostacyclin receptor
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Prostacyclin (PGI2) is continuously produced by healthy vascular endothelial cells. It inhibits platelet activation through interaction with the Gs-coupled receptor PTGIR, leading to increased cAMP, a consequent increase in cAMP-dependent protein kinase activity which prevents increases of cytoplasmic [Ca2+] necessary for activation (Woulfe et al. 2001). PGI2 is also an effective vasodilator. These effects oppose the effects of thromboxane (TXA2), another eicosanoid, creating a balance of blood circulation and platelet activation.
Literature References
PubMed ID Title Journal Year
17164137 Human prostacyclin receptor structure and function from naturally-occurring and synthetic mutations

Douville, KL, Stitham, J, Arehart, EJ, Hwa, J, Gleim, SR

Prostaglandins Other Lipid Mediat 2007
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Cross References
BioModels Database
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-03-09)
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