Reactome | Activated prostacyclin receptor binds G-protein Gs

Activated prostacyclin receptor binds G-protein Gs

Stable Identifier

R-HSA-392852

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Activated prostacyclin receptor binds G-protein Gs

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human prostacyclin receptor (IP) and G-protein alpha (s) physically interact through contacts between the IP iLP1 domain and the C-terminal residues of the G alpha (s) protein.

Literature References

PubMed ID	Title	Journal	Year
16460020	Solution structure of the first intracellular loop of prostacyclin receptor and implication of its interaction with the C-terminal segment of G alpha s protein Zhang, L, Wu, J, Ruan, KH	Biochemistry	2006

Participants

Input

Output

Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

Prostacyclin signalling through prostacyclin receptor

Authored

Akkerman, JW (2009-06-03)

Reviewed

Kunapuli, SP (2010-06-07)

Created

Jupe, S (2009-03-09)