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Activated prostacyclin receptor binds G-protein Gs
Stable Identifier
R-HSA-392852
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Prostacyclin signalling through prostacyclin receptor (Homo sapiens)
Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)
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The human prostacyclin receptor (IP) and G-protein alpha (s) physically interact through contacts between the IP iLP1 domain and the C-terminal residues of the G alpha (s) protein.
Literature References
PubMed ID
Title
Journal
Year
16460020
Solution structure of the first intracellular loop of prostacyclin receptor and implication of its interaction with the C-terminal segment of G alpha s protein
Ruan, KH
,
Zhang, L
,
Wu, J
Biochemistry
2006
Participants
Input
Heterotrimeric G-protein Gs (inactive) [plasma membrane]
(Homo sapiens)
PTGIR:PGI2 [plasma membrane]
(Homo sapiens)
Output
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane]
(Homo sapiens)
Participates
as an event of
Prostacyclin signalling through prostacyclin receptor (Homo sapiens)
Authored
Akkerman, JW (2009-06-03)
Reviewed
Kunapuli, SP (2010-06-07)
Created
Jupe, S (2009-03-09)
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