Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PIK3R5 [cytosol]
Stable Identifier
R-HSA-392289
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PI3-kinase p101 subunit, PI3R5_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
GPVI stimulates PI3K beta, gamma (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
PI3K alpha, beta, gamma [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
Co-stimulation by ICOS (Homo sapiens)
PI3K binds ICOS (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PIK3C(1) [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)
PIK3(2) [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI3K bound to EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through PI3Kgamma (Homo sapiens)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
G-protein beta-gamma:PI3K gamma [plasma membrane] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
Gbeta:gamma recruits PI3K gamma (Homo sapiens)
G-protein beta-gamma:PI3K gamma [plasma membrane] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
PI3K gamma [cytosol] (Homo sapiens)
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
PIK3R5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WYR1 PIK3R5
Gene Names
PIK3R5
Chain
chain:1-880
Reference Genes
BioGPS Gene:23533 PIK3R5
COSMIC (genes):PIK3R5 PIK3R5
CTD Gene:23533 PIK3R5
dbSNP Gene:23533 PIK3R5
ENSEMBL:ENSG00000141506 PIK3R5
HGNC:30035 PIK3R5
KEGG:hsa:23533 PIK3R5
Monarch:23533 PIK3R5
NCBI Gene:23533 PIK3R5
OMIM:611317 PIK3R5
UCSC:Q8WYR1 PIK3R5
Reference Transcript
RefSeq:NM_001251852.1 PIK3R5
RefSeq:NM_001251851.1 PIK3R5
RefSeq:NM_001142633.2 PIK3R5
RefSeq:NM_014308.3 PIK3R5
RefSeq:NM_001251853.1 PIK3R5
RefSeq:NM_001251855.1 PIK3R5
Other Identifiers
11721761_a_at
11721762_a_at
16841083
220566_PM_at
220566_at
227645_PM_at
227645_at
23533
3744682
3744683
3744684
3744685
3744686
3744687
3744688
3744689
3744690
3744691
3744692
3744693
3744694
3744695
3744696
3744697
3744698
3744699
3744700
3744701
3744702
3744703
3744704
3744705
3744706
3744709
3744710
3744711
3744712
3744714
3744715
3744716
3744717
3744718
3744720
3744721
3744722
3744734
3744736
49831_at
8012558
A_23_P66540
A_23_P66543
GE80421
GE88539
GO:0002376
GO:0003824
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005942
GO:0005943
GO:0005944
GO:0006629
GO:0006955
GO:0007186
GO:0016020
GO:0016301
GO:0016740
GO:0031683
GO:0034451
GO:0043226
GO:0043406
GO:0043491
GO:0046488
GO:0046935
GO:0051897
GO:0098772
HMNXSV003029826
HMNXSV003056142
Hs.38664.0.A1_3p_at
ILMN_1681067
PH_hs_0014312
PH_hs_0037294
TC17001124.hg
g7657432_3p_at
Participates
as a component of
PIK3CG:PIK3R5 [cytosol] (Homo sapiens)
as a member of
PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
Inferred To
PIK3R5 [cytosol]
(Bos taurus)
PIK3R5 [cytosol]
(Canis familiaris)
PIK3R5 [cytosol]
(Dictyostelium discoideum)
PIK3R5 [cytosol]
(Gallus gallus)
PIK3R5 [cytosol]
(Sus scrofa)
Pik3r5 [cytosol]
(Mus musculus)
Pik3r5 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_055123.2
,
NP_001238780.1
,
NP_001238784.1
,
NP_001136105.1
,
NP_001238782.1
,
NP_001238781.1
Guide to Pharmacology - Targets
2506
ENSEMBL
ENST00000611902
,
ENSP00000477795
,
ENST00000623421
,
ENSP00000484211
,
ENST00000616147
,
ENST00000447110
,
ENSG00000141506
,
ENSP00000392812
,
ENST00000581552
,
ENSP00000485280
,
ENSP00000462433
OpenTargets
ENSG00000141506
GeneCards
PIK3R5
HPA
ENSG00000141506-PIK3R5
PRO
Q8WYR1
Pharos - Targets
Q8WYR1
Orphanet
PIK3R5
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text