Reactome | Pik3r5 [cytosol]

Pik3r5 [cytosol]

Stable Identifier

R-MMU-392289

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

PIK3R5, Q5SW28

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Regulation of T cell activation by CD28 family (Mus musculus)
    - Co-stimulation by CD28 (Mus musculus)
      - CD28 dependent PI3K/Akt signaling (Mus musculus)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
        
        PI3K binds CD28 (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
    - Co-stimulation by ICOS (Mus musculus)
      - PI3K binds ICOS (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
        
        ICOS:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        Activator:PI3K [plasma membrane] (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
        
        ICOS:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - Activator:PI3K [plasma membrane] (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
        
        ICOS:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
- Signaling by Erythropoietin (Mus musculus)
  - Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Mus musculus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        PI3K alpha, gamma [cytosol] (Mus musculus)
        
        PIK3CG:PIK3R5 [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
      - PI3K alpha, gamma [cytosol] (Mus musculus)
        
        PIK3CG:PIK3R5 [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
        
        PI3K alpha, gamma [cytosol] (Mus musculus)
        
        PIK3CG:PIK3R5 [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
      - PI3K alpha, gamma [cytosol] (Mus musculus)
        
        PIK3CG:PIK3R5 [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
    - EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - PI3K alpha, gamma [cytosol] (Mus musculus)
        
        PIK3CG:PIK3R5 [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
      - PI3K bound to EPOR [plasma membrane] (Mus musculus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Mus musculus)
        
        PI3K alpha, gamma [cytosol] (Mus musculus)
        
        PIK3CG:PIK3R5 [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        PI3K alpha, gamma [cytosol] (Mus musculus)
        
        PIK3CG:PIK3R5 [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
        
        PI3K alpha, gamma [cytosol] (Mus musculus)
        
        PIK3CG:PIK3R5 [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G-protein beta:gamma signalling (Mus musculus)
      - G beta:gamma signalling through PI3Kgamma (Mus musculus)
        
        G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)
        
        G-protein beta-gamma:PI3K gamma [plasma membrane] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
        
        Gbeta:gamma recruits PI3K gamma (Mus musculus)
        
        G-protein beta-gamma:PI3K gamma [plasma membrane] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)
        
        PI3K gamma [cytosol] (Mus musculus)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)
        
        Pik3r5 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q5SW28 Pik3r5

Gene Names

Pik3r5

Chain

chain:1-871

Reference Genes

BioGPS Gene:320207 Pik3r5

KEGG:mmu:320207 Pik3r5

Monarch:320207 Pik3r5

NCBI Gene:320207 Pik3r5

UCSC:Q5SW28 Pik3r5

Reference Transcript

Other Identifiers

10377265

115395_at

1434980_at

17251303

320207

4336775

4426579

4458039

4472685

4489916

4516468

4518231

4526365

4745884

4769104

4871637

4896043

4902286

4916160

4969704

5000191

5036442

5045110

5084839

5093495

5125758

5162999

5192161

5250434

5254963

5339703

5361286

5377917

5378725

5529935

5577393

5585340

A_51_P173331

A_55_P2716871

GE1481340

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005944

GO:0006629

GO:0007186

GO:0016020

GO:0016301

GO:0031683

GO:0034451

GO:0043406

GO:0043491

GO:0046488

GO:0046935

GO:0051897

ILMN_1234494

ILMN_2585405

mMC025713

Participates

as a component of

PIK3CG:PIK3R5 [cytosol] (Mus musculus)

as a member of

PI3-kinase gamma, regulatory subunit [cytosol] (Mus musculus)

Other forms of this molecule

Pik3r5 [cytosol]

Inferred From

PIK3R5 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_796294.2, XP_006533611.1

ENSEMBL

ENSMUSG00000020901, ENSMUSP00000021283, ENSMUST00000021283

PRO

Q5SW28

MGI

2443588

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