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PIK3R5 [cytosol]
Stable Identifier
R-CFA-392289
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PIK3R5, A0A8I3MY22
Locations in the PathwayBrowser
Expand all
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
GPVI stimulates PI3K beta, gamma (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI3K alpha, beta, gamma [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Regulation of T cell activation by CD28 family (Canis familiaris)
Co-stimulation by CD28 (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
PI3K binds CD28 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
Co-stimulation by ICOS (Canis familiaris)
PI3K binds ICOS (Canis familiaris)
Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PIK3C(1) [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)
PIK3(2) [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
PI3K bound to EPOR [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through PI3Kgamma (Canis familiaris)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)
G-protein beta-gamma:PI3K gamma [plasma membrane] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
Gbeta:gamma recruits PI3K gamma (Canis familiaris)
G-protein beta-gamma:PI3K gamma [plasma membrane] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
PI3K gamma [cytosol] (Canis familiaris)
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
PIK3R5 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MY22
Gene Names
PIK3R5
Reference Genes
BioGPS Gene:612805 PIK3R5
ENSEMBL:ENSCAFG00845001127.1
Monarch:612805 PIK3R5
NCBI Gene:612805 PIK3R5
UCSC:A0A8I3MY22 PIK3R5
Reference Transcript
RefSeq:XM_038536858.1 PIK3R5
RefSeq:XM_038665577.1 PIK3R5
Other Identifiers
612805
CfaAffx.26601.1.S1_at
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005942
GO:0005944
GO:0007186
GO:0016020
GO:0034451
GO:0046935
GO:0051897
Participates
as a component of
PIK3CG:PIK3R5 [cytosol] (Canis familiaris)
as a member of
PI3-kinase gamma, regulatory subunit [cytosol] (Canis familiaris)
Inferred From
PIK3R5 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_038392786.1
,
XP_038521505.1
ENSEMBL
ENSCAFP00845001556
,
ENSCAFG00845001127
,
ENSCAFT00845001982
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