PAKs phosphorylate MLC

Stable Identifier
R-HSA-3928640
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Myosin II regulatory light chain (MLC) acts downstream of serine/threonine-protein kinase PAK (PAK) to mediate its effect on spine morphogenesis and excitatory synapse formation. PAK directly phosphorylates MLC on serine 19. MLC phosphorylation could promote dendritic spine morphogenesis by stabilizing the actin network at this site (Zhang et al. 2005).

Literature References
PubMed ID Title Journal Year
15800193 A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC

Zhang, H, Webb, DJ, Asmussen, H, Niu, S, Horwitz, AF

J. Neurosci. 2005
10047984 Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK)

Chew, TL, Masaracchia, RA, Goeckeler, ZM, Wysolmerski, RB

J. Muscle Res. Cell. Motil. 1998
Participants
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hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane]
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Activity
Orthologous Events
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