Reactome | Serotonin receptors

Serotonin receptors

Stable Identifier

R-HSA-390666

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Serotonin (5-HT) is a monoamine neurotransmitter that plays an important role as a modulator of anger, aggression, body temperature, mood, sleep, sexuality, appetite, metabolism, as well as stimulating vomiting. Several classes of drugs target the 5-HT system including some antidepressants, antipsychotics, anxiolytics, antiemetics and antimigraine drugs. The activity of 5-HT is modulated by 5-HT receptors, made up of seven families (5-HT1-7). All but 5-HT3 (ligand-gated ion channel) are GPCRs and these receptors bind different G proteins resulting in differing outcomes (Hoyer D et al, 1994; Kitson SL, 2007).

Literature References

PubMed ID	Title	Journal	Year
17897004	5-hydroxytryptamine (5-HT) receptor ligands Kitson, SL	Curr Pharm Des	2007
7938165	International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin) Martin, GR, Clarke, DE, Saxena, PR, Fozard, JR, Hoyer, D, Hartig, PR, Mylecharane, EJ, Humphrey, PP	Pharmacol Rev	1994