Serotonin receptors

Stable Identifier
R-HSA-390666
Type
Pathway
Species
Homo sapiens
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Serotonin receptors
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Serotonin (5-HT) is a monoamine neurotransmitter that plays an important role as a modulator of anger, aggression, body temperature, mood, sleep, sexuality, appetite, metabolism, as well as stimulating vomiting. Several classes of drugs target the 5-HT system including some antidepressants, antipsychotics, anxiolytics, antiemetics and antimigraine drugs. The activity of 5-HT is modulated by 5-HT receptors, made up of seven families (5-HT1-7). All but 5-HT3 (ligand-gated ion channel) are GPCRs and these receptors bind different G proteins resulting in differing outcomes (Hoyer D et al, 1994; Kitson SL, 2007).

Literature References
PubMed ID Title Journal Year
7938165 International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)

Hoyer, D, Clarke, DE, Fozard, JR, Hartig, PR, Martin, GR, Mylecharane, EJ, Saxena, PR, Humphrey, PP

Pharmacol Rev 1994
17897004 5-hydroxytryptamine (5-HT) receptor ligands

Kitson, SL

Curr Pharm Des 2007
Participants
Events
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Orthologous Events
Serotonin receptors (Bos taurus)
Serotonin receptors (Caenorhabditis elegans)
Serotonin receptors (Canis familiaris)
Serotonin receptors (Danio rerio)
Serotonin receptors (Drosophila melanogaster)
Serotonin receptors (Gallus gallus)
Serotonin receptors (Mus musculus)
Serotonin receptors (Rattus norvegicus)
Serotonin receptors (Sus scrofa)
Serotonin receptors (Xenopus tropicalis)
Authored
Jassal, B  (2009-02-12)
Reviewed
D'Eustachio, P  (2009-03-02)
Created
Jassal, B  (2009-02-10)