The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. There are three subtypes; 2A (Stam NJ et al, 1992), 2B (Kursar JD et al, 1994; Schmuck K et al, 1994) and 2C (Stam NJ et al, 1994). The actions of these receptors are mediated by coupling with the G protein alpha-q/11 subtype which activates phospholipase C, increasing cellular levels of inositol trisphosphate (IP3) and diacylglycerol (DAG) (Lucaites VL et al, 1996).
Baez, M, Lucaites, VL, Nelson, DL, Wainscott, DB
de Boer, T, Van Alebeek, C, Olijve, W, van Delft, AM, Vanderheyden, P, Stam, NJ, Klomp, J
Baez, M, Nelson, DL, Kursar, JD, Wainscott, DB
Van Alebeek, C, Van Huizen, F, Olijve, W, Dijkema, R, Stam, NJ, Brands, J, Tonnaer, JA
Lübbert, H, Schmuck, K, Engels, P, Ullmer, C
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