5-HT2 receptor can bind serotonin

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R-HSA-390930
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Homo sapiens
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The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. There are three subtypes; 2A (Stam NJ et al, 1992), 2B (Kursar JD et al, 1994; Schmuck K et al, 1994) and 2C (Stam NJ et al, 1994). The actions of these receptors are mediated by coupling with the G protein alpha-q/11 subtype which activates phospholipase C, increasing cellular levels of inositol trisphosphate (IP3) and diacylglycerol (DAG) (Lucaites VL et al, 1996).

Literature References
PubMed ID Title Journal Year
8809227 Receptor subtype and density determine the coupling repertoire of the 5-HT2 receptor subfamily

Baez, M, Lucaites, VL, Nelson, DL, Wainscott, DB

Life Sci 1996
7895773 Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor

de Boer, T, Van Alebeek, C, Olijve, W, van Delft, AM, Vanderheyden, P, Stam, NJ, Klomp, J

Eur J Pharmacol 1994
8078486 Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor

Baez, M, Nelson, DL, Kursar, JD, Wainscott, DB

Mol Pharmacol 1994
1330647 Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes

Van Alebeek, C, Van Huizen, F, Olijve, W, Dijkema, R, Stam, NJ, Brands, J, Tonnaer, JA

Eur J Pharmacol 1992
8143856 Cloning and functional characterization of the human 5-HT2B serotonin receptor

L├╝bbert, H, Schmuck, K, Engels, P, Ullmer, C

FEBS Lett 1994
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