Reactome | 5-HT2 receptor can bind serotonin

5-HT2 receptor can bind serotonin

Stable Identifier

R-HSA-390930

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        5-HT2 receptor can bind serotonin (Homo sapiens)

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The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. There are three subtypes; 2A (Stam NJ et al, 1992), 2B (Kursar JD et al, 1994; Schmuck K et al, 1994) and 2C (Stam NJ et al, 1994). The actions of these receptors are mediated by coupling with the G protein alpha-q/11 subtype which activates phospholipase C, increasing cellular levels of inositol trisphosphate (IP3) and diacylglycerol (DAG) (Lucaites VL et al, 1996).

Literature References

PubMed ID	Title	Journal	Year
8809227	Receptor subtype and density determine the coupling repertoire of the 5-HT2 receptor subfamily Lucaites, VL, Nelson, DL, Wainscott, DB, Baez, M	Life Sci	1996
7895773	Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor Stam, NJ, Vanderheyden, P, Van Alebeek, C, Klomp, J, de Boer, T, van Delft, AM, Olijve, W	Eur J Pharmacol	1994
8078486	Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor Kursar, JD, Nelson, DL, Wainscott, DB, Baez, M	Mol Pharmacol	1994
1330647	Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes Stam, NJ, Van Huizen, F, Van Alebeek, C, Brands, J, Dijkema, R, Tonnaer, JA, Olijve, W	Eur J Pharmacol	1992
8143856	Cloning and functional characterization of the human 5-HT2B serotonin receptor Schmuck, K, Ullmer, C, Engels, P, Lübbert, H	FEBS Lett	1994