HTR1 and 5A receptors can bind serotonin

Stable Identifier
Reaction [binding]
Homo sapiens
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5-hydroxytryptamine receptors (HTRs), once bound to serotonin (5HT), act on the CNS where they induce neuronal and presynaptic inhibition and behavioural effects. In humans, there are five subtypes of the HTR1 receptor, designated 1A-1F (there is no 1C type) (Stam et al. 1992, Hamblin et al. 1992, Weinshank et al. 1992, Zgombick et al. 1992, Adham et al. 1993). HTR1A is described in a separate reaction. HTR5A is expressed in human brain (Rees S et al, 1994) and has an inhibitory effect like HTR1s. Both these subtypes mediate their actions by coupling with the G protein alpha-i/o subtype (Lin et al. 2002, Francken et al. 1998), inhibiting adenylate cyclase activity and thereby decreasing cellular cAMP levels.

Literature References
PubMed ID Title Journal Year
12145108 Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family

Cowen, DS, Johnson-Farley, NN, Lin, SL, Setya, S

Br J Pharmacol 2002
9865521 The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells

Jurzak, M, Francken, BJ, Vanhauwe, JF, Leysen, JE, Luyten, WH

Eur J Pharmacol 1998
1565658 Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta

Weinshank, RL, Branchek, TA, Hartig, PR, Macchi, MJ, Zgombick, JM

Proc Natl Acad Sci U S A 1992
8380639 Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase

Weinshank, RL, Bard, J, Schecter, LE, Branchek, TA, Durkin, M, Kao, HT, Urquhart, D, Hartig, PR, Adham, N, Olsen, M

Proc Natl Acad Sci U S A 1993
1330647 Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes

Van Alebeek, C, Van Huizen, F, Olijve, W, Dijkema, R, Stam, NJ, Brands, J, Tonnaer, JA

Eur J Pharmacol 1992
1513320 Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor

Weinshank, RL, Macchi, M, Branchek, TA, Hartig, PR, Schechter, LE, Zgombick, JM

Mol Pharmacol 1992
1315531 Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity

Metcalf, MA, Karpells, S, McGuffin, RW, Hamblin, MW

Biochem Biophys Res Commun 1992
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