Reactome | HTR1 and 5A receptors can bind serotonin

HTR1 and 5A receptors can bind serotonin

Stable Identifier

R-HSA-390929

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        HTR1 and 5A receptors can bind serotonin (Homo sapiens)

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HTR1 and 5A receptors can bind serotonin

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5-hydroxytryptamine receptors (HTRs), once bound to serotonin (5HT), act on the CNS where they induce neuronal and presynaptic inhibition and behavioural effects. In humans, there are five subtypes of the HTR1 receptor, designated 1A-1F (there is no 1C type) (Stam et al. 1992, Hamblin et al. 1992, Weinshank et al. 1992, Zgombick et al. 1992, Adham et al. 1993). HTR1A is described in a separate reaction. HTR5A is expressed in human brain (Rees S et al, 1994) and has an inhibitory effect like HTR1s. Both these subtypes mediate their actions by coupling with the G protein alpha-i/o subtype (Lin et al. 2002, Francken et al. 1998), inhibiting adenylate cyclase activity and thereby decreasing cellular cAMP levels.

Literature References

PubMed ID	Title	Journal	Year
12145108	Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family Lin, SL, Setya, S, Johnson-Farley, NN, Cowen, DS	Br J Pharmacol	2002
9865521	The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells Francken, BJ, Jurzak, M, Vanhauwe, JF, Luyten, WH, Leysen, JE	Eur J Pharmacol	1998
1565658	Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta Weinshank, RL, Zgombick, JM, Macchi, MJ, Branchek, TA, Hartig, PR	Proc Natl Acad Sci U S A	1992
8380639	Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase Adham, N, Kao, HT, Schecter, LE, Bard, J, Olsen, M, Urquhart, D, Durkin, M, Hartig, PR, Weinshank, RL, Branchek, TA	Proc Natl Acad Sci U S A	1993
1330647	Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes Stam, NJ, Van Huizen, F, Van Alebeek, C, Brands, J, Dijkema, R, Tonnaer, JA, Olijve, W	Eur J Pharmacol	1992
1513320	Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor Zgombick, JM, Schechter, LE, Macchi, M, Hartig, PR, Branchek, TA, Weinshank, RL	Mol Pharmacol	1992
1315531	Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity Hamblin, MW, Metcalf, MA, McGuffin, RW, Karpells, S	Biochem Biophys Res Commun	1992