Amine ligand-binding receptors

Stable Identifier
Homo sapiens
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The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs.
Literature References
PubMed ID Title Journal Year
15148138 The neurobiology of dopamine signaling

Girault, JA, Greengard, P

Arch Neurol 2004
17073660 Muscarinic acetylcholine receptors

Ishii, M, Kurachi, Y

Curr Pharm Des 2006
17897004 5-hydroxytryptamine (5-HT) receptor ligands

Kitson, SL

Curr Pharm Des 2007
7938162 International Union of Pharmacology nomenclature of adrenoceptors

Molinoff, PB, Eikenberg, DC, Ruffolo RR, Jr, Lefkowitz, RJ, Hieble, JP, Bylund, DB, Minneman, KP, Trendelenburg, U, Langer, SZ

Pharmacol Rev 1994
11459929 Trace amines: identification of a family of mammalian G protein-coupled receptors

Lichtblau, H, Bonini, JA, Jones, KA, Branchek, TA, Borowsky, B, Pu, X, Artymyshyn, R, Boyle, N, Pathirana, S, Ochoa, FY, Gerald, C, Ogozalek, KL, Kouranova, E, Raddatz, R, Adham, N, Durkin, MM, Lakhlani, PP

Proc Natl Acad Sci U S A 2001
9311023 International Union of Pharmacology. XIII. Classification of histamine receptors

Ganellin, CR, Shankley, NP, Schwartz, JC, Levi, R, Timmerman, H, Hill, SJ, Haas, HL, Young, JM, Schunack, W

Pharmacol Rev 1997
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