Reactome | HTR1A binds 5HT

HTR1A binds 5HT

Stable Identifier

R-HSA-9693347

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

HTR1A receptor binds serotonin

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        HTR1A binds 5HT (Homo sapiens)

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5-hydroxytryptamine receptors 1A (HTR1A), once bound to their physiological ligand serotonin (5HT), act on the CNS where they induce neuronal and presynaptic inhibition and behavioural effects (Stam et al. 1992). HTR1A mediates its actions by coupling with the G protein alpha-i/o subtype (Lin et al. 2002, Francken et al. 1998), inhibiting adenylate cyclase activity and thereby decreasing cellular cAMP levels.

Literature References

PubMed ID	Title	Journal	Year
12145108	Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family Lin, SL, Setya, S, Johnson-Farley, NN, Cowen, DS	Br J Pharmacol	2002
9865521	The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells Francken, BJ, Jurzak, M, Vanhauwe, JF, Luyten, WH, Leysen, JE	Eur J Pharmacol	1998
1330647	Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes Stam, NJ, Van Huizen, F, Van Alebeek, C, Brands, J, Dijkema, R, Tonnaer, JA, Olijve, W	Eur J Pharmacol	1992