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ACTA1 [cytosol]
Stable Identifier
R-HSA-390534
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Actin, alpha skeletal muscle, ACTS_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
Regulation of CDH1 Expression and Function (Homo sapiens)
Regulation of CDH1 Function (Homo sapiens)
CDH1 forms homotypic trans-dimers (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Homotypic CDH1 trans-dimer cluster [plasma membrane] (Homo sapiens)
Homotypic CDH1 trans-dimer [plasma membrane] (Homo sapiens)
Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
trans-Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
CDH1-associated CTNNA1 binds F-actin (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
CDH1-associated CTNNA1 binds VCL (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
DGC complex binds AGRN and HSPG2 (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
DGC:laminin complex binds F-actin (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Striated Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Calcium Binds Troponin-C (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68133 ACTA1
Gene Names
ACTA1, ACTA
Chain
initiator methionine:1, chain:2-377, chain:3-377
Reference Genes
BioGPS Gene:58 ACTA1
COSMIC (genes):ACTA1 ACTA1
CTD Gene:58 ACTA1
dbSNP Gene:58 ACTA1
ENSEMBL:ENSG00000143632 ACTA1
HGNC:129 ACTA1
KEGG:hsa:58 ACTA1
Monarch:58 ACTA1
NCBI Gene:58 ACTA1
OMIM:102610 ACTA1
UCSC:P68133 ACTA1
Reference Transcript
RefSeq:NM_001100.4 ACTA1
Other Identifiers
11743108_a_at
11743109_x_at
11753504_x_at
16700274
203872_PM_at
203872_at
2459838
2459839
2459841
2459842
2459843
2459844
2459845
2459846
2459847
2459848
2459849
2459850
2459851
2459853
2459855
2459856
2459857
2459858
2459859
31737_at
3621802
58
7924910
A_23_P1102
GE566813
GO:0000166
GO:0001725
GO:0003012
GO:0005198
GO:0005200
GO:0005515
GO:0005524
GO:0005615
GO:0005737
GO:0005829
GO:0005856
GO:0005865
GO:0005884
GO:0006936
GO:0010628
GO:0015629
GO:0016787
GO:0017022
GO:0030017
GO:0030027
GO:0030175
GO:0030240
GO:0043531
GO:0044297
GO:0048741
GO:0048856
GO:0070062
GO:0072562
GO:0090131
HMNXSV003019973
ILMN_2125869
M20543_at
PH_hs_0000172
TC01003945.hg
TC06001971.hg
g5016087_3p_at
Participates
as a member of
alpha Actin [cytosol] (Homo sapiens)
Inferred To
acta1a [cytosol]
(Danio rerio)
acta1 [cytosol]
(Xenopus tropicalis)
act-5 [cytosol]
(Caenorhabditis elegans)
ACTA1 [cytosol]
(Bos taurus)
ACTA1 [cytosol]
(Canis familiaris)
ACTA1 [cytosol]
(Gallus gallus)
Arp53D [cytosol]
(Drosophila melanogaster)
Acta1 [cytosol]
(Mus musculus)
Acta1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001091.1
ENSEMBL
ENST00000366684
,
ENSP00000355645
,
ENSG00000143632
OpenTargets
ENSG00000143632
GeneCards
ACTA1
HPA
ENSG00000143632-ACTA1
PRO
P68133
Pharos - Targets
P68133
GlyGen
P68133
Orphanet
ACTA1
PDB
9DUV
,
9DUU
,
7RNV
,
7RNS
,
7RNU
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14565 DMC1
1
DMC1 [nucleoplasm]
(R-HSA-912490)
0.527
2
UniProt:Q16665 HIF1A
7
HIF1A [nucleoplasm]
(R-HSA-1234135)
HIF1A [cytosol]
(R-HSA-1234102)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
0.527
2
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