Reactome | Acta1 [cytosol]

Acta1 [cytosol]

Stable Identifier

R-MMU-390534

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ACTA1, P68134

Locations in the PathwayBrowser

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Cell-Cell communication (Mus musculus)

- Cell junction organization (Mus musculus)
  - Cell-cell junction organization (Mus musculus)
    - Adherens junctions interactions (Mus musculus)
      - Activation of STAT3 by cadherin engagement (Mus musculus)
        
        CDH1 forms homotypic trans-dimers (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        Homotypic CDH1 trans-dimer cluster [plasma membrane] (Mus musculus)
        
        Homotypic CDH1 trans-dimer [plasma membrane] (Mus musculus)
        
        Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        CDH1-associated CTNNA1 binds F-actin (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        CDH1-associated CTNNA1 binds VCL (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination (Mus musculus)
        
        Engaged CDH1,(CDH11) [plasma membrane] (Mus musculus)
        
        Homotypic CDH1 trans-dimer cluster [plasma membrane] (Mus musculus)
        
        Homotypic CDH1 trans-dimer [plasma membrane] (Mus musculus)
        
        Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
      - Regulation of Homotypic Cell-Cell Adhesion (Mus musculus)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Mus musculus)
        
        Regulation of CDH1 Expression and Function (Mus musculus)
        
        Regulation of CDH1 Function (Mus musculus)
        
        CDH1 forms homotypic trans-dimers (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        Homotypic CDH1 trans-dimer cluster [plasma membrane] (Mus musculus)
        
        Homotypic CDH1 trans-dimer [plasma membrane] (Mus musculus)
        
        Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        CDH1-associated CTNNA1 binds F-actin (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        CDH1-associated CTNNA1 binds VCL (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Mus musculus)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)

Extracellular matrix organization (Mus musculus)

- Non-integrin membrane-ECM interactions (Mus musculus)
  - Formation of the dystrophin-glycoprotein complex (DGC) (Mus musculus)
    - DGC complex binds AGRN and HSPG2 (Mus musculus)
      - DGC complex:laminins:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
      - DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Mus musculus)
        
        DGC complex:laminins:F-actin [plasma membrane] (Mus musculus)
        
        F-actin (all) [cytosol] (Mus musculus)
        
        actins:ATP [cytosol] (Mus musculus)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)

Muscle contraction (Mus musculus)

- Striated Muscle Contraction (Mus musculus)
  - ATP Hydrolysis By Myosin (Mus musculus)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Mus musculus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Mus musculus)
        
        alpha Actin Chain [cytosol] (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Mus musculus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Mus musculus)
        
        alpha Actin Chain [cytosol] (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
  - Calcium Binds Troponin-C (Mus musculus)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Mus musculus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Mus musculus)
        
        alpha Actin Chain [cytosol] (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
    - Inactive Sarcomere Protein Complex [cytosol] (Mus musculus)
      - Thin Filament [cytosol] (Mus musculus)
        
        alpha Actin Chain [cytosol] (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
  - Myosin Binds ATP (Mus musculus)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Mus musculus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Mus musculus)
        
        alpha Actin Chain [cytosol] (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Mus musculus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Mus musculus)
        
        alpha Actin Chain [cytosol] (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
  - Release Of ADP From Myosin (Mus musculus)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Mus musculus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Mus musculus)
        
        alpha Actin Chain [cytosol] (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Mus musculus)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Mus musculus)
        
        alpha Actin Chain [cytosol] (Mus musculus)
        
        alpha Actin [cytosol] (Mus musculus)
        
        Acta1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P68134

Gene Names

Acta1

Reference Genes

BioGPS Gene:11459 Acta1

ENSEMBL:ENSMUSG00000031972

KEGG:mmu:11459 Acta1

Monarch:11459 Acta1

NCBI Gene:11459 Acta1

UCSC:P68134 Acta1

Reference Transcript

Other Identifiers

100381_at

10582592

11459

1427735_a_at

17513995

4509290

4637279

4682966

4728376

4744426

4824082

4840317

4913229

4986463

5273198

5289111

5306347

5330511

5559173

GE32927

GO:0000166

GO:0001725

GO:0005515

GO:0005524

GO:0005737

GO:0005856

GO:0005865

GO:0005884

GO:0010628

GO:0015629

GO:0016787

GO:0030017

GO:0030027

GO:0030175

GO:0030240

GO:0032991

GO:0044297

GO:0048741

GO:0048856

GO:0090131

ILMN_2738825

m12347_s_at

mMC018239

Participates

as a member of

alpha Actin [cytosol] (Mus musculus)

Inferred From

ACTA1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_033736.1, NP_001258970.1

ENSEMBL

ENSMUSP00000034453, ENSMUST00000034453, ENSMUSG00000031972

PRO

P68134

GlyGen

P68134

MGI

87902

PDB

7QIN, 7NEP, 4B1U, 6KLL, 6KLN, 7AQK, 7QIM

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